Trial reportBiological psychiatry2009
Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence.
Trial report in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 57 citations in OpenAlex.
- Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation.Brain, behavior, and immunity · 2015Trial
- A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.JAMA psychiatry · 2013Trial
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Elevations in interleukin-8 levels in individuals with alcohol use disorder and clinical insomnia symptoms.Alcohol, clinical & experimental research · 2024Article
- Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.Temperature (Austin, Tex.) · 2023Article
- Effect of short-term mindfulness-based stress reduction on sleep quality in male patients with alcohol use disorder.Frontiers in psychiatry · 2023Article
- Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system.Therapeutic advances in musculoskeletal disease · 2021Review
- Current and potential pharmacological treatment options for insomnia in patients with alcohol use disorder in recovery.Neuropsychopharmacology reports · 2020Review
- Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Sleep and inflammation: partners in sickness and in health.Nature reviews. Immunology · 2019Review
- The Sleep-Immune Crosstalk in Health and Disease.Physiological reviews · 2019Review
- Tumor necrosis factor alpha in sleep regulation.Sleep medicine reviews · 2018Review
- Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis.Psychosomatic medicine · 2017Article
- Alcohol Dependence and Its Relationship With Insomnia and Other Sleep Disorders.Alcoholism, clinical and experimental research · 2016Review
- Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.Pharmacological reviews · 2016Review
- Polysomnographic measures of sleep in cocaine dependence and alcohol dependence: Implications for age-related loss of slow wave, stage 3 sleep.Addiction (Abingdon, England) · 2016Article
- Why sleep is important for health: a psychoneuroimmunology perspective.Annual review of psychology · 2015Review
- Hormonal and dietary characteristics in obese human subjects with and without food addiction.Nutrients · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn alcohol dependence, markers of inflammation are associated with increases in rapid eye movement (REM) sleep, which is thought to be a prognostic indicator of alcohol relapse. This study was undertaken to test whether blockade of biologically active tumor necrosis factor-alpha (TNF-alpha) normalizes REM sleep in alcohol-dependent adults.
methodsIn a randomized, placebo-controlled, double-blind, crossover trial, 18 abstinent alcohol-dependent male adults received a single dose of etanercept (25 mg) versus placebo in a counterbalanced order. Polysomnographic sleep was measured at baseline and for 3 nights after the acute dose of etanercept or placebo.
resultsCompared with placebo, administration of etanercept produced significant decreases in the amount and percentage of REM sleep. Decreases in REM sleep were robust and approached low levels typically found in age-comparable control subjects. Individual differences in biologically active drug as indexed by circulating levels of soluble tumor necrosis factor receptor II negatively correlated with the percentage of REM sleep.
conclusionsPharmacologic neutralization of TNF-alpha activity is associated with significant reductions in REM sleep in abstinent alcohol-dependent patients. These data suggest that circulating levels of TNF-alpha may have a physiologic role in the regulation of REM sleep in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.