ArticleAmerican journal of obstetrics and gynecology2009
Enhanced estrogen-induced proliferation in obese rat endometrium.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Changes in fecal microbiota of dairy cows with and without endometritis.BMC veterinary research · 2025Article
- Mesenchymal stem cells from adipose tissue prone to lose their stemness associated markers in obesity related stress conditions.Scientific reports · 2024Article
- How Do Microorganisms Influence the Development of Endometriosis? Participation of Genital, Intestinal and Oral Microbiota in Metabolic Regulation and Immunopathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- DoesCancers · 2022Review
- The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer.International journal of molecular sciences · 2022Review
- Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights.Pharmacological research · 2022Review
- Review
- Associations Between Endometriosis and Gut Microbiota.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Article
- Skeletal and Uterotrophic Effects of Endoxifen in Female Rats.Endocrinology · 2017Article
- Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression.Molecular nutrition & food research · 2016Article
- Therapeutic options for management of endometrial hyperplasia.Journal of gynecologic oncology · 2016Review
- CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity.Gynecologic oncology · 2014Article
- Chemopreventive effects of metformin on obesity-associated endometrial proliferation.American journal of obstetrics and gynecology · 2013Article
- Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer.Discovery medicine · 2012Review
- Understanding obesity and endometrial cancer risk: opportunities for prevention.American journal of obstetrics and gynecology · 2011Review
- Prospective evaluation of insulin resistance among endometrial cancer patients.American journal of obstetrics and gynecology · 2011Article
- Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil.Sao Paulo medical journal = Revista paulista de medicina · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe tested the hypothesis that the proliferative estrogen effect on the endometrium is enhanced in obese vs lean animals. STUDY
designUsing Zucker fa/fa obese rats and lean control, we examined endometrial cell proliferation and the expression patterns of certain estrogen-regulated proproliferative and antiproliferative genes after short-term treatment with estradiol.
resultsNo significant morphologic/histologic difference was seen between the obese rats and the lean rats. Estrogen-induced proproliferative genes cyclin A and c-Myc messenger RNA expression were significantly higher in the endometrium of obese rats compared with those of the lean control. Expression of the antiproliferative gene p27Kip1 was suppressed by estrogen treatment in both obese and lean rats; however, the decrease was more pronounced in obese rats. Estrogen more strongly induced the antiproliferative genes retinaldehyde dehydrogenases 2 and secreted frizzled-related protein 4 in lean rats but had little or no effect in obese rats.
conclusionEnhancement of estrogen-induced endometrial proproliferative gene expression and suppression of antiproliferative gene expression was seen in the endometrium of obese vs lean animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.