ArticleStatistics in medicine2009
Mediation analysis with principal stratification.
Article in Statistics in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02129244 (A Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes
Who cites it
35 citing papers in PubMed.
- Bayesian inference for the causal effect of mediation.Biometrics · 2012Trial
- Identification of complier and noncomplier average causal effects in the presence of latent missing-at-random (LMAR) outcomes: a unifying view and choices of assumptions.Biostatistics (Oxford, England) · 2024Article
- Semiparametric Latent Class Analysis of Recurrent Event Data.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2022Article
- Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects.Journal of the Royal Statistical Society. Series C, Applied statistics · 2021Article
- Instrumental variable analyses for causal inference: Application to multilevel analyses of the alliance-outcome relation.Psychotherapy research : journal of the Society for Psychotherapy Research · 2020Article
- A Bayesian semiparametric latent variable approach to causal mediation.Statistics in medicine · 2018Article
- Identifying Mechanisms of Behavior Change in Psychosocial Alcohol Treatment Trials: Improving the Quality of Evidence from Mediational Analyses.Journal of studies on alcohol and drugs · 2018Article
- Links between causal effects and causal association for surrogacy evaluation in a gaussian setting.Statistics in medicine · 2017Article
- Latent Class Survival Models Linked by Principal Stratification to Investigate Heterogenous Survival Subgroups Among Individuals With Early-Stage Kidney Cancer.Journal of the American Statistical Association · 2017Article
- Estimating controlled direct effects of restrictivefeeding practices in the 'Early dieting in girls' study.Journal of the Royal Statistical Society. Series C, Applied statistics · 2016Article
- Identification and Estimation of Causal Mechanisms in Clustered Encouragement Designs: Disentangling Bed Nets using Bayesian Principal Stratification.Journal of the American Statistical Association · 2016Article
- Causal inference with longitudinal outcomes and non-ignorable drop-out: Estimating the effect of living alone on cognitive decline.Journal of the Royal Statistical Society. Series C, Applied statistics · 2016Article
- Estimating the health benefit of reducing indoor air pollution in a randomized environmental intervention.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2015Article
- Inference for environmental intervention studies using principal stratification.Statistics in medicine · 2014Article
- Causal inference in longitudinal comparative effectiveness studies with repeated measures of a continuous intermediate variable.Statistics in medicine · 2014Article
- Sensitivity plots for confounder bias in the single mediator model.Evaluation review · 2013Article
- Assessing mediation using marginal structural models in the presence of confounding and moderation.Psychological methods · 2012Article
- Comments: Should Principal Stratification Be Used to Study Mediational Processes?Journal of research on educational effectiveness · 2012Article
- On causal inference in the presence of interference.Statistical methods in medical research · 2012Article
- Conditioning on intermediates in perinatal epidemiology.Epidemiology (Cambridge, Mass.) · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In assessing the mechanism of treatment efficacy in randomized clinical trials, investigators often perform mediation analyses by analyzing if the significant intent-to-treat treatment effect on outcome occurs through or around a third intermediate or mediating variable: indirect and direct effects, respectively. Standard mediation analyses assume sequential ignorability, i.e. conditional on covariates the intermediate or mediating factor is randomly assigned, as is the treatment in a randomized clinical trial. This research focuses on the application of the principal stratification (PS) approach for estimating the direct effect of a randomized treatment but without the standard sequential ignorability assumption. This approach is used to estimate the direct effect of treatment as a difference between expectations of potential outcomes within latent subgroups of participants for whom the intermediate variable behavior would be constant, regardless of the randomized treatment assignment. Using a Bayesian estimation procedure, we also assess the sensitivity of results based on the PS approach to heterogeneity of the variances among these principal strata. We assess this approach with simulations and apply it to two psychiatric examples. Both examples and the simulations indicated robustness of our findings to the homogeneous variance assumption. However, simulations showed that the magnitude of treatment effects derived under the PS approach were sensitive to model mis-specification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.