ArticlePathology oncology research : POR2009
Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers.
Article in Pathology oncology research : POR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation.Cancer cell international · 2024Article
- N-Cadherin Distinguishes Intrahepatic Cholangiocarcinoma from Liver Metastases of Ductal Adenocarcinoma of the Pancreas.Cancers · 2022Article
- Angiotensin II type 1 receptor localizes at the blood-bile barrier in humans and pigs.Histochemistry and cell biology · 2022Article
- Article
- Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts.Hepatology communications · 2020Article
- Tight Junction Proteins and the Biology of Hepatobiliary Disease.International journal of molecular sciences · 2020Review
- Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.Pathology oncology research : POR · 2020Review
- Decreased expression of ZO-1 is associated with tumor metastases in liver cancer.Oncology letters · 2019Article
- Low Expression of Occludin in the Melanoma Patient.Iranian journal of pathology · 2019Article
- Abnormally expressed JunB transactivated by IL-6/STAT3 signaling promotes uveal melanoma aggressiveness via epithelial-mesenchymal transition.Bioscience reports · 2018Article
- MicroRNA‑103 regulates tumorigenesis in colorectal cancer by targeting ZO‑1.Molecular medicine reports · 2018Article
- Low expression of occludin: a predictor of poor prognosis in esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2017Article
- Bile duct epithelial tight junctions and barrier function.Tissue barriers · 2013Review
- Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.World journal of surgical oncology · 2013Article
- Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma.Journal of dental research · 2013Review
- Upregulated ZO-1 correlates with favorable survival of gastrointestinal stromal tumor.Medical oncology (Northwood, London, England) · 2013Article
- Article
- Identification of PEG10 and TSG101 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.Pathology oncology research : POR · 2011Article
- Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.Acta pharmacologica Sinica · 2011Review
- Tight junction-associated signaling pathways modulate cell proliferation in uveal melanoma.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin. Each plays important role in the maintenance of epithelial cell polarity and regulation of cell growth and differentiation. Our aim was to investigate ZO-1, occludin, and E-cadherin immunohistochemical reactions in tissue microarray blocks containing 57 normal and 62 neoplastic biliary tract samples. We demonstrated that the tight junction components ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract (normal intrahepatic and extrahepatic bile ducts, gallbladder) as compared with their normal sites of origin. These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations.
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