ArticleInternational journal of colorectal disease2009
Small intestinal submucosa for reinforcement of colonic anastomosis.
Article in International journal of colorectal disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- External coating of colonic anastomoses: a systematic review.International journal of colorectal disease · 2012Pooled it
- Short-term outcomes of a novel anti-reflux biologic flap technique versus double flap technique after laparoscopic proximal gastrectomy: a retrospective cohort study.Surgical endoscopy · 2026Article
- Hemopatch serosal reinforcement in right colectomy: transforming anastomotic leak patterns and severity compared to second-line suture technique-a 10-Year Retrospective Cohort Study of 352 patients.Updates in surgery · 2026Article
- Clinical progress and prospects of biodegradable intestinal stents.American journal of translational research · 2026Review
- Regeneration of the Gastrointestinal Tract After Using a Small Intestine Submucosa Patch-A Rat Model.Biomedicines · 2025Article
- Novel external reinforcement device for gastrointestinal anastomosis in an experimental study.BMC surgery · 2023Article
- The clinical effectiveness of staple line reinforcement with different matrix used in surgery.Frontiers in bioengineering and biotechnology · 2023Review
- In vivo performance of a bilayer wrap to prevent abdominal adhesions.Acta biomaterialia · 2020Article
- Poly-ε-caprolactone scaffold for the reinforcement of stapled small intestinal anastomoses: a randomized experimental study.Langenbeck's archives of surgery · 2019Article
- Development of hyaluronan-based membranes for the healing of intestinal surgical wounds: a preliminary study.Journal of materials science. Materials in medicine · 2019Article
- International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract.International journal of colorectal disease · 2016Article
- The use of murine-derived fundic organoids in studies of gastric physiology.The Journal of physiology · 2015Article
- Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa.Journal of tissue engineering and regenerative medicine · 2015Article
- Staple line/anastomotic reinforcement and other adjuncts: do they make a difference?Clinics in colon and rectal surgery · 2014Review
- Bovine pericardium patch wrapping intestinal anastomosis improves healing process and prevents leakage in a pig model.PloS one · 2014Article
- Collagen fleeces do not improve colonic anastomotic strength but increase bowel obstructions in an experimental rat model.International journal of colorectal disease · 2011Article
- Extracellular matrices for gastrointestinal surgery: ex vivo testing and current applications.World journal of gastroenterology · 2010Article
- Anastomotic sealing by extracellular matrices (ECM) improves healing of colonic anastomoses in the critical early phase.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- The Contribution of a Collagen Patch Coated With Fibrin Glue in Sealing Upper Gastrointestinal Defects: An Experimental Study.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent materials have been evaluated for anastomotic reinforcement to prevent gastrointestinal anastomotic leakage. In this experimental study, small intestinal submucosa (SIS) was tested as a sealing for stapled colonic anastomosis in a porcine model. The aims of this study were to determine the macroscopic and microscopic outcomes and to evaluate the safety and feasibility of applying SIS for anastomotic sealing. MATERIALS AND
methodsCircular stapled anastomoses were performed in 18 pigs. Standard anastomosis in the control group (n = 8) was compared to an SIS-sealed anastomosis in the study group (n = 10). After 30 days, anastomotic segments were examined for macroscopic and microscopic regeneration and their resistance to mechanical stress. Furthermore, animal survival and clinical course were evaluated.
resultsNone of the animals developed anastomotic leakage, intraabdominal abscess, or peritonitis. Shrinkage of SIS was evident in nine of ten animals. Encapsulation and displacement of the SIS patches were seen in two animals. Quantity of anastomotic granulation tissue and rate of complete mucosal coverage of anastomotic line were increased in SIS-sealed anastomoses without reaching significance. Moreover, no significant differences were found in the rate of survival of the animals, anastomotic stricture formation, intraabdominal adhesions, anastomotic bursting pressure, and microscopic healing parameters of the anastomosis between stapled colonic standard anastomosis and anastomosis protected by SIS.
conclusionThe results of this study indicate a safe use of SIS for anastomotic reinforcement in a porcine model. Adverse effects like strictures, increased adhesions, and anastomotic abscesses were absent. Promoting effects on colonic wound healing by SIS were microscopically evident. The results argue for a careful clinical evaluation in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.