ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2009
Lung respiratory rhythm and pattern generation in the bullfrog: role of neurokinin-1 and mu-opioid receptors.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Activation of respiratory-related bursting in an isolated medullary section from adult bullfrogs.The Journal of experimental biology · 2023Article
- The rostral medulla of bullfrog tadpoles contains critical lung rhythmogenic and chemosensitive regions across metamorphosis.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Review
- Evolution of lung breathing from a lungless primitive vertebrate.Respiratory physiology & neurobiology · 2016Article
- Respiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta).Respiratory physiology & neurobiology · 2016Article
- Chronic nicotine and ethanol exposure both disrupt central ventilatory responses to hypoxia in bullfrog tadpoles.Respiratory physiology & neurobiology · 2013Article
- Regulation of respiratory-related hypoglossal motor output by α₁ adrenergic and serotonin 5-HT₃ receptor activation in isolated adult turtle brainstems.Respiratory physiology & neurobiology · 2012Article
- Neuroplasticity of the central hypercapnic ventilatory response: teratogen-induced impairment and subsequent recovery during development.Developmental neurobiology · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Location of the lung respiratory rhythm generator (RRG) in the bullfrog brainstem was investigated by examining neurokinin-1 and mu-opioid receptor (NK1R, muOR) colocalization by immunohistochemistry and characterizing the role of these receptors in lung rhythm and episodic pattern generation. NK1R and muOR occurred in brainstems from all developmental stages. In juvenile bullfrogs a distinct area of colocalization was coincident with high-intensity fluorescent labeling of muOR; high-intensity labeling of muOR was not distinctly and consistently localized in tadpole brainstems. NK1R labeling intensity did not change with development. Similarity in colocalization is consistent with similarity in responses to substance P (SP, NK1R agonist) and DAMGO (muOR agonist) when bath applied to bullfrog brainstems of different developmental stages. In early stage tadpoles and juvenile bullfrogs, SP increased and DAMGO decreased lung burst frequency. In juvenile bullfrogs, SP increased lung burst frequency, episode frequency, but decreased number of lung bursts per episode and lung burst duration. In contrast, DAMGO decreased lung burst frequency and burst cycle frequency, episode frequency, and number of lung bursts per episode but increased all other lung burst parameters. Based on these results, we hypothesize that NK1R and muOR colocalization together with a metamorphosis-related increase in muOR intensity marks the location of the lung RRG but not necessarily the lung episodic pattern generator.
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