ArticleIntensive care medicine2009
Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children.
Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
- Regional citrate anticoagulation for pediatric CRRT using integrated citrate software and physiological sodium concentration solutions.Pediatric nephrology (Berlin, Germany) · 2014Trial
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Nutrition delivery in infants with kidney failure on extracorporeal kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association of Dietary Micronutrient Intake and the Metabolome in Children with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Optimizing nutrition and metabolism in a severely burned patient during prolonged continuous renal replacement therapy: a case report.Frontiers in nutrition · 2025Article
- Thiamine deficiency secondary to intestinal surgery leading to shoshin beriberi and Wernicke encephalopathy: a case report.Frontiers in pediatrics · 2025Article
- Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China.Journal of intensive medicine · 2024Article
- Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Nutritional management of children with acute kidney injury-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Metabolic and nutritional aspects in continuous renal replacement therapy.Journal of intensive medicine · 2023Review
- An Overview of Type B Lactic Acidosis Due to Thiamine (B1) Deficiency.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- The effect of continuous venovenous hemodiafiltration on amino acid delivery, clearance, and removal in children.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Fluid Restriction Contributes to Poor Nutritional Adequacy in Patients With Congenital Heart Disease Receiving Renal Replacement Therapy.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2022Article
- Nutrition in Pediatric Extracorporeal Membrane Oxygenation: A Narrative Review.Frontiers in nutrition · 2021Review
- Micronutrient status during paediatric critical illness: A scoping review.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Clearance of micronutrients during continuous renal replacement therapy.Critical care (London, England) · 2020Article
- Micronutrient deficiency in critical illness: an invisible foe?Intensive care medicine · 2019Article
- Feeding modality is a barrier to adequate protein provision in children receiving continuous renal replacement therapy (CRRT).Pediatric nephrology (Berlin, Germany) · 2019Observational
- Vitamin and trace element deficiencies in the pediatric dialysis patient.Pediatric nephrology (Berlin, Germany) · 2018Review
- Nutritional management in the critically ill child with acute kidney injury: a review.Pediatric nephrology (Berlin, Germany) · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance.
methodsCritically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5.
resultsWe studied 15 children aged 7.7 +/- 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m(2). CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m(2) on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05).
conclusionsNutrient losses by CVHHD may impact adequate nutrition provision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.