ArticlePloS one2009
The effect of transposable element insertions on gene expression evolution in rodents.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Transposable Elements: Distribution, Polymorphism, and Climate Adaptation inFrontiers in plant science · 2022Article
- Movements of transposable elements contribute to the genomic plasticity and species diversification in an asexually reproducing nematode pest.Evolutionary applications · 2021Article
- Regulation of LINE-1 Elements by miR-128 Is Not Conserved in Mouse Embryonic Stem Cells.Frontiers in genetics · 2018Article
- Coevolution between transposable elements and recombination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Exogenous gypsy insulator sequences modulate transgene expression in the malaria vector mosquito, Anopheles stephensi.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Effect of heavy metals on silencing of engineered long interspersed element-1 retrotransposon in nondividing neuroblastoma cell line.Iranian biomedical journal · 2013Article
- Spreading of heterochromatin is limited to specific families of maize retrotransposons.PLoS genetics · 2012Article
- Spatiotemporal transcription of the P element and the 412 retrotransposon during embryogenesis of Drosophila melanogaster and D. willistoni.Genetics and molecular biology · 2011Article
- Distributions of transposable elements reveal hazardous zones in mammalian introns.PLoS computational biology · 2011Article
- The struggle for life of the genome's selfish architects.Biology direct · 2011Review
- Transposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Effect of the transposable element environment of human genes on gene length and expression.Genome biology and evolution · 2011Article
- Genes devoid of full-length transposable element insertions are involved in development and in the regulation of transcription in human and closely related species.Journal of molecular evolution · 2010Article
- A problem with the correlation coefficient as a measure of gene expression divergence.Genetics · 2009Article
- The transposon Galileo generates natural chromosomal inversions in Drosophila by ectopic recombination.PloS one · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundMany genomes contain a substantial number of transposable elements (TEs), a few of which are known to be involved in regulating gene expression. However, recent observations suggest that TEs may have played a very important role in the evolution of gene expression because many conserved non-genic sequences, some of which are know to be involved in gene regulation, resemble TEs.
resultsHere we investigate whether new TE insertions affect gene expression profiles by testing whether gene expression divergence between mouse and rat is correlated to the numbers of new transposable elements inserted near genes. We show that expression divergence is significantly correlated to the number of new LTR and SINE elements, but not to the numbers of LINEs. We also show that expression divergence is not significantly correlated to the numbers of ancestral TEs in most cases, which suggests that the correlations between expression divergence and the numbers of new TEs are causal in nature. We quantify the effect and estimate that TE insertion has accounted for approximately 20% (95% confidence interval: 12% to 26%) of all expression profile divergence in rodents.
conclusionsWe conclude that TE insertions may have had a major impact on the evolution of gene expression levels in rodents.
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