ArticleThe Journal of clinical investigation1991
Illegitimate transcription. Application to the analysis of truncated transcripts of the dystrophin gene in nonmuscle cultured cells from Duchenne and Becker patients.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Taking advantage of an old concept, "illegitimate transcription", for a proposed novel method of genetic diagnosis of McArdle disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Antisense PMO found in dystrophic dog model was effective in cells from exon 7-deleted DMD patient.PloS one · 2010Article
- Identification of seven novel cryptic exons embedded in the dystrophin gene and characterization of 14 cryptic dystrophin exons.Journal of human genetics · 2007Article
- A novel cryptic exon identified in the 3' region of intron 2 of the human dystrophin gene.Journal of human genetics · 2005Article
- An intragenic deletion/inversion event in the DMD gene determines a novel exon creation and results in a BMD phenotype.Human genetics · 2004Article
- Roles of Fas and Fas ligand during mammary gland remodeling.The Journal of clinical investigation · 2000Article
- Mapping of a new locus for autosomal recessive demyelinating Charcot-Marie-Tooth disease to 19q13.1-13.3 in a large consanguineous Lebanese family: exclusion of MAG as a candidate gene.American journal of human genetics · 2000Article
- The clinical and molecular genetic approach to Duchenne and Becker muscular dystrophy: an updated protocol.Journal of medical genetics · 1997Article
- Defects in RNA splicing and the consequence of shortened translational reading frames.American journal of human genetics · 1996Article
- Investigation of muscle disease.Journal of neurology, neurosurgery, and psychiatry · 1996Review
- Exon skipping and translation in patients with frameshift deletions in the dystrophin gene.American journal of human genetics · 1993Article
- Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young.The Journal of clinical investigation · 1993Article
- Alternative splicing of dystrophin mRNA complicates carrier determination: report of a DMD family.Journal of medical genetics · 1993Article
- Omission of exon 12 in cystic fibrosis transmembrane conductance regulator (CFTR) gene transcripts.Human genetics · 1992Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that there is a low level of transcription of tissue-specific genes in every cell type. In this study, we have taken advantage of this phenomenon, called illegitimate transcription, to analyze the muscle-type dystrophin mRNA in easily accessible cells such as lymphoid cells, fibroblasts, and peripheral blood cells from Duchenne and Becker muscular dystrophies with known internal gene deletion. The results showed that, in the studied regions surrounding the deletions, processing of truncated transcripts is identical in specific (muscle tissue) and in nonspecific cells (lymphoid cells). In Becker cases with out-of-frame deletions, the already described alternatively spliced species found in muscle samples were also found in nonspecific cells. These results demonstrate that illegitimate transcripts are a bona fide version of tissue-specific mRNA, and that they represent a useful material to investigate the qualitative consequences of gene defects at the mRNA level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.