ArticleBMC microbiology2009
Active immunization using exotoxin A confers protection against Pseudomonas aeruginosa infection in a mouse burn model.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 8 citations in OpenAlex.
- Hydrogel-Based Dressings and Multidisciplinary Care in Severe Pediatric Burns: A Case Report of Successful Healing and Hypertrophic Scar Prevention.The American journal of case reports · 2024Article
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- Relation between CarS expression and activation of carotenogenesis by stress inFrontiers in bioengineering and biotechnology · 2022Article
- Enhanced Healing Activity of Manuka Honey and Nitrofurazone Composite in Full-Thickness Burn Wounds in the Rabbit Model.Frontiers in veterinary science · 2022Article
- A comparative study on antibacterial activity of carvacrol and glutaraldehyde onJournal of environmental health science & engineering · 2021Article
- UnderstandingCells · 2020Review
- Contamination of wounds with fecal bacteria in immuno-suppressed mice.Scientific reports · 2020Article
- Design of a gold nanoprobe for the detection ofRSC advances · 2020Article
- Complications and Outcome of Electrical Burns in Manipal, India: 6-Year Institutional Report.World journal of plastic surgery · 2020Article
- Treatment of Second to Third-Degree Burns in A 2-Day-Old Infant: A Case Report.World journal of plastic surgery · 2020Article
- Prophylactic Tracheostomy for Inhalational Burns.World journal of plastic surgery · 2020Article
- The Effect of Short-Term Training Course by Nurses on Body Image in Patients with Burn Injuries.World journal of plastic surgery · 2019Article
- Article
- Mortality and Body Mass Index in Burn Patients: Experience from a Tertiary Referral Burn Center in Southern Iran.World journal of plastic surgery · 2019Article
- Investigating the Psychosocial Empowerment Interventions through Multimedia Education in Burn Patients.World journal of plastic surgery · 2019Article
- A Six-Year Study on Epidemiology of Electrical Burns in Northern Iran: Is It Time to Pay Attention?World journal of plastic surgery · 2019Article
- An Observational Study on Clothing Characteristics Involved as Major Contributors in Sustaining Domestic Burns Injuries.World journal of plastic surgery · 2019Article
- Novel pharmacotherapy for burn wounds: what are the advancements.Expert opinion on pharmacotherapy · 2019Review
- Prophylactic and therapeutic protection of human IgG purified from sera containing anti-exotoxin A titers against pneumonia caused byHuman vaccines & immunotherapeutics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPseudomonas aeruginosa is an important cause of nosocomial infection and may lead to septicemia and death. We evaluated the immunogenicity of semi-purified exotoxin A from the bacterium in a mouse burn model.
methodsThe toxoid was prepared from exotoxin A taken from toxigenic strains of P. aeruginosa (PA 103). 50 mice were immunized with the toxoid, burned with hot metal and infected with 1 x 10(8) CFU of toxigenic strains of P. aeruginosa (experimental group); 25 non-immunized mice were also burned and infected (control group). The mortality rate and presence of any exotoxin and P. aeruginosa in the sera, liver and spleen were determined.
resultsIn the experimental group, 2 mice died before the burns were administered and were excluded from the study. The remainder (48 mice) were challenged with a lethal dose of P. aeruginosa and followed for 70 days. 3 of these mice died. Neither P. aeruginosa nor exotoxin A was not detected in the liver, spleen or sera of the surviving mice. The protective efficacy of toxoid vaccination was therefore 93.8%. In the control group, all mice died from bacteremia and septicemia, most (80%) within 6 days, and P. aeruginosa and exotoxin A were isolated from sera, spleen and liver.
conclusionActive immunization of mice using a semi-purified exotoxin A derived from P. aeruginosa was 93.8% effective at protecting mice from subsequent P. aeruginosa infections in a mouse burn model.
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