ArticleJournal of cellular and molecular medicine2009
A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs).
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Identification and localization of telocyte-like cells in human umbilical cord stroma.Scientific reports · 2025Article
- A cellular regulator of the niche: telocyte.Tissue barriers · 2023Review
- Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling.International journal of molecular sciences · 2020Article
- Effect of cholesterol onWorld journal of gastrointestinal surgery · 2020Article
- Cardiac telocytes exist in the adult Xenopus tropicalis heart.Journal of cellular and molecular medicine · 2020Article
- Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes.Oncotarget · 2020Article
- Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium.Journal of arrhythmia · 2019Article
- Telocytes in the human sinoatrial node.Journal of cellular and molecular medicine · 2018Article
- Expression and distribution of the transient receptor potential cationic channel A1 (TRPA1) in the human clitoris-comparison to male penile erectile tissue.International journal of impotence research · 2017Article
- Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone.Frontiers in cardiovascular medicine · 2017Review
- Isolation, culture, purification and ultrastructural investigation of cardiac telocytes.Molecular medicine reports · 2016Article
- Ultrastructural identification of telocytes in the muscularis of chicken ileum.Experimental and therapeutic medicine · 2015Article
- CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling.Biology of reproduction · 2015Article
- Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes.PloS one · 2015Article
- Telocytes and putative stem cells in ageing human heart.Journal of cellular and molecular medicine · 2015Article
- iPSC-derived human mesenchymal stem cells improve myocardial strain of infarcted myocardium.Journal of cellular and molecular medicine · 2014Article
- New insights into the morphogenic role of stromal cells and their relevance for regenerative medicine. lessons from the heart.Journal of cellular and molecular medicine · 2014Review
- Electrophysiology of human cardiac atrial and ventricular telocytes.Journal of cellular and molecular medicine · 2014Article
- A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis.Journal of cellular and molecular medicine · 2014Article
- Cardiomyocyte regeneration.Cells · 2013Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence of a novel type of interstitial cells in the heart, interstitial Cajal-like cells (ICLCs), had been described for the first time in 2005. Their identification was mainly based on ultrastructural criteria: very long (tens up to hundreds of micrometres) and moniliform prolongations, which are extremely thin (less than 0.2 microm), below the resolving power of light microscopy. Myocardial ICLCs were also identified by methylene-blue vital staining, silver impregnation, and immunoreactivity for CD 34, vimentin, CD117/c-kit, etc. Although a series of studies provided evidence for the existence of ICLCs in human atria and rat ventricles, further investigations in other laboratories, using additional techniques, are required to substantiate the consistency of these findings. Here we provide further evidence for the existence of ICLCs in human and mammalian hearts (by transmission and scanning electron microscopy, as well as confocal laser scanning microscopy). Noteworthy, we confirm that ICLCs communicate with neighbouring cells via shedding (micro)vesicles. Although these so-called ICLCs represent a distinct type of cells, different from classical interstitial cells of Cajal, or fibroblasts, their role(s) in myocardium remain(s) to be established. Several hypotheses are proposed: (i) adult stromal (mesenchymal) stem cells, which might participate in cardiac repair/remodelling; (ii) intercellular signalling (e.g. via shedding microvesicles); (iii) chemo-mechanical transducers and (iv) players in pacemaking and/or arrhytmogenesis, and so on.
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