ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2009
Near-patient assays for diagnosis of influenza virus infection in adult patients.
Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Guidelines for the management of adult lower respiratory tract infections--full version.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2011Guideline
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- Single-Step Detection of the Influenza Virus Hemagglutinin Using Bacterially-Produced Quenchbodies.Sensors (Basel, Switzerland) · 2018Article
- A multicenter prospective study on the diagnostic performance of a new liquid rapid urease test for the diagnosis ofGut pathogens · 2017Article
- A study of the transferability of influenza case detection systems between two large healthcare systems.PloS one · 2017Article
- Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates.Emerging infectious diseases · 2015Article
- Signs and symptoms predicting influenza in children: a matched case-control analysis of prospectively collected clinical data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Clinical validation of a point-of-care multiplexed in vitro immunoassay using monoclonal antibodies (the MSD influenza test) in four hospitals in Vietnam.Journal of clinical microbiology · 2012Article
- Evaluation of direct immunofluorescence test with PCR for detection of novel influenza A (H1N1) virus during 2009 pandemic.Yonsei medical journal · 2011Article
- Feasibility of diagnosing influenza within 24 hours of symptom onset in children 1-3 years of age.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- New respiratory viruses and the elderly.The open respiratory medicine journal · 2011Article
- Failure of routine diagnostic methods to detect influenza in hospitalized older adults.Infection control and hospital epidemiology · 2010Article
- The diagnosis of viral respiratory disease in older adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Review
- Ruling out novel H1N1 influenza virus infection with direct fluorescent antigen testing.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
- [Interests and limitations of rapid diagnostic tests for respiratory and gastrointestinal viral diseases].Revue francophone des laboratoires : RFLArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid and reliable diagnosis of influenza is essential for identification of contagious patients and effective patient management. Near-patient assays allow establishment of the diagnosis within minutes in young children, and this study aimed to evaluate near-patient assays in relation to the patient's age. A total of 194 patients with laboratory-confirmed influenza A/H3N2 virus infection, diagnosed within a prospective cohort study, were included. Cryopreserved nasopharyngeal swabs collected from these patients were tested by four near-patient assays (Binax Now Influenza A&B, Quick S-Influ A/B, Influ-A&B Respi-Strip, and Actim Influenza A&B). The main outcome measure was sensitivity of the near-patient assays in relation to the age of patients. The Binax Now, Quick S-Influ, Influ-A&B Respi-Strip and Actim assays had overall sensitivities of 19%, 18%, 26%, and 40%, respectively. The estimated sensitivity for influenza A/H3N2 virus detection in nasopharyngeal swabs was 17-56% in children 1 year of age and decreased to 8-22% in patients 80 years of age (logistic regression). The sensitivity of the Influ-A&B Respi-Strip and Actim assays decreased significantly with increasing age (p 0.014 and p 0.033, respectively (logistic regression)), a trend for decrease was observed for the Binax Now assay (p 0.074 (logistic regression)), and the low sensitivity of the Quick S-Influ assay was similar in children and adults. Less than one-fourth of diagnosed influenza A/H3N2 virus infections can be identified in elderly patients using a near-patient assay. Consequently, near-patient assays are of limited value for confirming the diagnosis when influenza is clinically suspected in adults. Antiviral therapy and additional diagnostic procedures cannot be withheld on the basis of a negative near-patient assay result, particularly in adult patients.
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