ArticleAlimentary pharmacology & therapeutics2009
Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States.
Article in Alimentary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Celiac disease poses significant risk in developing depression, anxiety, headache, epilepsy, panic disorder, dysthymia: A meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Pooled it
- Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder.Medicine · 2016Pooled it
- Outcomes of sinus surgery in ambulatory patients with immune dysfunction.American journal of rhinology & allergyTrial
- Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025Review
- Celiac Disease-Narrative Review on Progress in Celiac Disease.Foods (Basel, Switzerland) · 2025Review
- Anxiety and Depression Among Adults and Children With Celiac Disease: A Meta-Analysis of Different Psychiatry Scales.Psychiatric research and clinical practice · 2024Review
- Epidemiological, Endoscopic, Clinical, and Pathological Features of Patients with Celiac Diseases in Southern Littoral of Caspian Sea.Middle East journal of digestive diseases · 2023Article
- Celiac Disease in the Elderly.Current treatment options in gastroenterology · 2022Article
- A philosophy of health: life as reality, health as a universal value.Palgrave communications · 2020Article
- Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy.Psychopharmacology · 2019Review
- Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review.Nutrients · 2018Review
- Article
- Psychotropic medication use among patients with celiac disease.BMC psychiatry · 2018Article
- Depression and insomnia among individuals with celiac disease or on a gluten-free diet in the USA: results from a national survey.European journal of gastroenterology & hepatology · 2017Article
- Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy.Diabetology & metabolic syndrome · 2016Review
- Extraintestinal manifestations of coeliac disease.Nature reviews. Gastroenterology & hepatology · 2015Review
- Hepatobiliary Quiz (Answers)-15 (2015).Journal of clinical and experimental hepatology · 2015Article
- Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population.The American journal of gastroenterology · 2015Article
- Psychological morbidity of celiac disease: A review of the literature.United European gastroenterology journal · 2015Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies yielded conflicting results regarding the presence of an association between coeliac disease (CD) and psychiatric disorders including depression. This association has not been studied in the United States.
aimTo determine the prevalence of psychiatric and autoimmune disorders in patients with CD in the US compared with control groups.
methodsIn a case control study, the prevalence of psychiatric and autoimmune disorders was compared in 600 CD patients, 200 irritable bowel syndrome (IBS) patients and 200 healthy controls.
resultsThe prevalence of depression in CD was 17.2% and was similar to that in IBS (18.5%, P = 0.74) and controls (16.0%, P = 0.79). Among CD patients, type I diabetes mellitus (DM) was identified as a significant risk factor for depression (P < 0.01) with 37% of patients with both CD and type I DM having clinical depression.
conclusionThe prevalence of depression in CD is similar to that in other chronic gastrointestinal diseases and healthy controls. However, there is a markedly elevated risk of depression in patients with both type I DM and CD. Differing rates of type 1 DM among coeliac populations may account for disparity in published rates of depression in patients with CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.