ArticleActa paediatrica (Oslo, Norway : 1992)2009
Agrichemicals in surface water and birth defects in the United States.
Article in Acta paediatrica (Oslo, Norway : 1992), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nitrate contamination in drinking water and adverse reproductive and birth outcomes: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Atrazine and pregnancy outcomes: a systematic review of epidemiologic evidence.Birth defects research. Part B, Developmental and reproductive toxicology · 2014Pooled it
- Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.Toxicology · 2026Article
- Exposure to pesticides in drinking water during pregnancy and risk of congenital malformations: a systematic review protocol.BMJ open · 2026Article
- Integrated Analysis of Neuroendocrine and Neurotransmission Pathways Following Developmental Atrazine Exposure in Zebrafish.International journal of molecular sciences · 2024Article
- Article
- Influence of Four Veterinary Antibiotics on Constructed Treatment Wetland Nitrogen Transformation.Toxics · 2024Article
- Developmental regulation of cellular metabolism is required for intestinal elongation and rotation.Development (Cambridge, England) · 2024Article
- Adverse developmental impacts in progeny of zebrafish exposed to the agricultural herbicide atrazine during embryogenesis.Environment international · 2023Article
- Examining Relationships Between Groundwater Nitrate Concentrations in Drinking Water and Landscape Characteristics to Understand Health Risks.GeoHealth · 2022Article
- A cross-sectional study of brownfields and birth defects.Birth defects research · 2022Article
- Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters.Environmental science and pollution research international · 2021Article
- Review
- The dietary risk index system: a tool to track pesticide dietary risks.Environmental health : a global access science source · 2020Article
- Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers.Environmental science and pollution research international · 2020Article
- Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Low prevalence of anti-xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer.Cancer medicine · 2019Article
- Residential mobility of pregnant women and implications for assessment of spatially-varying environmental exposures.Journal of exposure science & environmental epidemiology · 2018Article
- Residential mobility during pregnancy in Urban Gansu, China.Health & place · 2018Article
- Atrazine Contamination of Drinking Water and Adverse Birth Outcomes in Community Water Systems with Elevated Atrazine in Ohio, 2006⁻2008.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate if live births conceived in months when surface water agrichemicals are highest are at greater risk for birth defects.
methodsMonthly concentrations during 1996-2002 of nitrates, atrazine and other pesticides were calculated using United States Geological Survey's National Water Quality Assessment data. Monthly United States birth defect rates were calculated for live births from 1996 to 2002 using United States Centers for Disease Control and Prevention natality data sets. Birth defect rates by month of last menstrual period (LMP) were then compared to pesticide/nitrate means using logistical regression models.
resultsMean concentrations of agrichemicals were highest in April-July. Total birth defects, and eleven of 22 birth defect subcategories, were more likely to occur in live births with LMPs between April and July. A significant association was found between the season of elevated agrichemicals and birth defects.
conclusionElevated concentrations of agrichemicals in surface water in April-July coincided with higher risk of birth defects in live births with LMPs April-July. While a causal link between agrichemicals and birth defects cannot be proven from this study an association might provide clues to common factors shared by both variables.
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