ReviewNature clinical practice. Rheumatology2009
New insights into the pathogenesis and genetics of psoriatic arthritis.
Review in Nature clinical practice. Rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology of psoriasis in Italy: burden, cost, comorbidities and patients' satisfaction. A systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.American journal of human genetics · 2012Pooled it
- Discriminant validity, responsiveness and reliability of the arthritis-specific Work Productivity Survey assessing workplace and household productivity in patients with psoriatic arthritis.Arthritis research & therapy · 2014Trial
- The influence of genetic factors on the clinical manifestations and response to systemic treatment of plaque psoriasis.Archives of dermatological research · 2025Review
- Diabetes and obesity burden and improvements in cardiometabolic parameters in patients with psoriasis or psoriatic arthritis receiving apremilast in a real-world setting.JAAD international · 2024Article
- Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.Experimental dermatology · 2022Article
- Endometriosis, Psoriasis, and Psoriatic Arthritis: A Prospective Cohort Study.American journal of epidemiology · 2022Article
- The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis-Real-World Data from Dermatology Practice.Journal of personalized medicine · 2021Article
- Evaluating Inflammatory Versus Mechanical Back Pain in Individuals with Psoriatic Arthritis: A Review of the Literature.Rheumatology and therapy · 2020Review
- The role of the histamine HBritish journal of pharmacology · 2020Review
- Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management.Therapeutic advances in musculoskeletal disease · 2020Review
- Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity.Experimental and molecular pathology · 2019Article
- Increased frequency of activated CD8Scientific reports · 2019Article
- Personalized medicine - a new reality in psoriatic arthritis?Nature reviews. Rheumatology · 2018Article
- Current concepts and unmet needs in psoriatic arthritis.Clinical rheumatology · 2018Review
- T Cell Hierarchy in the Pathogenesis of Psoriasis and Associated Cardiovascular Comorbidities.Frontiers in immunology · 2018Review
- Early Recognition and Treatment Heralds Optimal Outcomes: the Benefits of Combined Rheumatology-Dermatology Clinics and Integrative Care of Psoriasis and Psoriatic Arthritis Patients.Current rheumatology reports · 2017Review
- Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies.American journal of public health · 2016Review
- Association between Genetic Polymorphisms and Response to Anti-TNFs in Patients with Inflammatory Bowel Disease.International journal of molecular sciences · 2016Review
- Clinical and immunogenetic characterization in psoriatic arthritis patients.Clinical rheumatology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Psoriasis vulgaris and psoriatic arthritis (PsA) are inter-related heritable diseases. Psoriatic skin is characterized by hyperproliferative, poorly differentiated keratinocytes and severe inflammation. Psoriatic joints are characterized by highly inflamed synovia and entheses with focal erosions of cartilage and bone. Genetic analyses have uncovered risk factors shared by both psoriasis and PsA. Predisposition to psoriasis and PsA arising from common variation is most strongly conferred by the HLA class I region. Other genetic risk factors implicate the interleukin (IL)-23 pathway and the induction and regulation of type 17 T-helper cells in the pathogenesis of both diseases. Secretion of cytokines, such as IL-22 and IL-17, could result in the hyperproliferative phenotype of keratinocytes and potentially synoviocytes, leading to a vicious cycle of cellular proliferation and inflammation in both the skin and joints. In synovial tissue, disease-related cytokines could also promote osteoclast formation, resulting in bone erosion. The next step will be to identify genetic risk factors specifically associated with PsA. Although therapies that target tumor necrosis factor are often highly successful in the treatment of both diseases, genetic findings are likely to lead to the development of treatments tailored to an individual's genetic profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.