ReviewFly
Fruit flies and intellectual disability.
Review in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Long-term Memory Testing in Children With Typical Development and Neurodevelopmental Disorders: Remote Web-based Image Task Feasibility Study.JMIR pediatrics and parenting · 2023Article
- Intellectual disability and autism spectrum disorders 'on the fly': insights fromDisease models & mechanisms · 2019Review
- Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains.Journal of visualized experiments : JoVE · 2017Article
- Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model.EBioMedicine · 2016Article
- Social communication of predator-induced changes in Drosophila behavior and germ line physiology.eLife · 2015Article
- A novel paradigm for nonassociative long-term memory in Drosophila: predator-induced changes in oviposition behavior.Genetics · 2015Article
- PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment.Frontiers in psychiatry · 2015Review
- Drosophila adult olfactory shock learning.Journal of visualized experiments : JoVE · 2014Article
- Human intellectual disability genes form conserved functional modules in Drosophila.PLoS genetics · 2013Article
- Attraction to and learning from social cues in fruitfly larvae.Proceedings. Biological sciences · 2013Article
- Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.PloS one · 2013Article
- A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.Disease models & mechanisms · 2013Article
- Fragile x mental retardation 1 and filamin a interact genetically in Drosophila long-term memory.Frontiers in neural circuits · 2010Article
- Understanding intellectual disability through RASopathies.Journal of physiology, ParisReview
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mental retardation--known more commonly nowadays as intellectual disability--is a severe neurological condition affecting up to 3% of the general population. As a result of the analysis of familial cases and recent advances in clinical genetic testing, great strides have been made in our understanding of the genetic etiologies of mental retardation. Nonetheless, no treatment is currently clinically available to patients suffering from intellectual disability. Several animal models have been used in the study of memory and cognition. Established paradigms in Drosophila have recently captured cognitive defects in fly mutants for orthologs of genes involved in human intellectual disability. We review here three protocols designed to understand the molecular genetic basis of learning and memory in Drosophila and the genes identified so far with relation to mental retardation. In addition, we explore the mental retardation genes for which evidence of neuronal dysfunction other than memory has been established in Drosophila. Finally, we summarize the findings in Drosophila for mental retardation genes for which no neuronal information is yet available. All in all, this review illustrates the impressive overlap between genes identified in human mental retardation and genes involved in physiological learning and memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.