ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- Frailty and pituitary surgery: a systematic review.Pituitary · 2025Pooled it
- Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial.Menopause (New York, N.Y.) · 2014Trial
- Optimizing cardiovascular pharmacotherapy in older adults with frailty.Nature reviews. Cardiology · 2026Review
- Gender differences in the association between physical frailty and cognitive function among older adults: A cross-sectional study in rural Guizhou, China.Scientific reports · 2026Article
- Longer duration of intact hypothalamic-pituitary-gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs.Scientific reports · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Construction and validation of a risk prediction model for postoperative frailty in older adults:a multicenter study.BMC geriatrics · 2025Article
- Frailty and risk of gastrointestinal bleeding: a prospective cohort study based on UK biobank.Frontiers in public health · 2025Article
- The brain-body energy conservation model of aging.Nature aging · 2024Review
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- Development and Validation of an Abridged Physical Frailty Phenotype for Clinical Use: A Cohort Study Among Kidney Transplant Candidates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Frailty index and risk of cardiovascular diseases: a mendelian randomization study.Annals of translational medicine · 2022Article
- Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer.Current oncology (Toronto, Ont.) · 2022Article
- A study on the prevalence and related factors of frailty and pre-frailty in the older population with diabetes in China: A national cross-sectional study.Frontiers in public health · 2022Article
- Prevalence of frailty and prediction of mortality in Chinese cancer patients using a frailty index-based clinical algorithm-A multicentre study.Cancer medicine · 2021Observational
- Cortisol and Dehydroepiandrosterone Response to Adrenocorticotropic Hormone and Frailty in Older Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Frailty subtypes and recovery in older survivors of acute respiratory failure: a pilot study.Thorax · 2021Article
- Review
- Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.Biogerontology · 2021Article
- Post-ICU Frailty: Does Critical Illness Accelerate Aging?Critical care medicine · 2020Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlterations in anabolic hormones are theorized to contribute to aging and frailty, with most studies focusing on the relationship between individual hormones and specific age-associated diseases. We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones.
methodsThe relationships of serum levels of total IGF-1, DHEAS, and free testosterone (T) with frailty status (nonfrail, prefrail, or frail) were analyzed in 494 women aged 70-79 years enrolled in the Women's Health and Aging Studies I or II. Using multivariate polytomous regression, we calculated the odds of frailty for deficiency in each hormone (defined as the bottom quartile of the hormone) individually, as well as for a count of the hormones.
resultsFor each hormone, in adjusted analyses, those with the deficiency were more likely to be frail than those without the deficiency, although this did not achieve statistical significance (IGF-1: odds ratio [OR] 1.82, confidence interval [CI] 0.81-4.08; DHEAS: OR 1.68, CI 0.77-3.69; free T: OR 2.03, CI 0.89-4.64). Compared with those with no hormonal deficiencies, those with one deficiency were not more likely to be frail (OR 1.15, CI 0.49-2.68), whereas those with two or three deficiencies had a very high likelihood of being frail (OR 2.79, CI 1.06-7.32), in adjusted models.
conclusionsThe absolute burden of anabolic hormonal deficiencies is a stronger predictor of frailty status than the type of hormonal deficiency, and the relationship is nonlinear. These analyses suggest generalized endocrine dysfunction in the frailty syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.