ArticleApplied and environmental microbiology2009
Evolutionary history of the phl gene cluster in the plant-associated bacterium Pseudomonas fluorescens.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
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- Analysis of Structural Genomic Diversity inFrontiers in plant science · 2020Article
- Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.Chembiochem : a European journal of chemical biology · 2019Article
- Molecular cloning, expression, and characterization of acyltransferase from Pseudomonas protegens.Applied microbiology and biotechnology · 2018Article
- Antifungal Bacteria on Woodland Salamander Skin Exhibit High Taxonomic Diversity and Geographic Variability.Applied and environmental microbiology · 2017Article
- Distribution of 2,4-Diacetylphloroglucinol Biosynthetic Genes among theFrontiers in microbiology · 2017Article
- Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens.Journal of bacteriology · 2015Article
- Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans.Clinical microbiology reviews · 2014Review
- Genome sequence reveals that Pseudomonas fluorescens F113 possesses a large and diverse array of systems for rhizosphere function and host interaction.BMC genomics · 2013Article
- Genome sequence of the biocontrol strain Pseudomonas fluorescens F113.Journal of bacteriology · 2012Article
- Intraspecific genotypic richness and relatedness predict the invasibility of microbial communities.The ISME journal · 2011Article
- Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria.BMC microbiology · 2010Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas fluorescens is of agricultural and economic importance as a biological control agent largely because of its plant association and production of secondary metabolites, in particular 2,4-diacetylphloroglucinol (2,4-DAPG). This polyketide, which is encoded by the eight-gene phl cluster, has antimicrobial effects on phytopathogens, promotes amino acid exudation from plant roots, and induces systemic resistance in plants. Despite its importance, 2,4-DAPG production is limited to a subset of P. fluorescens strains. Determination of the evolution of the phl cluster and understanding the selective pressures promoting its retention or loss in lineages of P. fluorescens will help in the development of P. fluorescens as a viable and effective inoculant for application in agriculture. In this study, genomic and sequence-based approaches were integrated to reconstruct the phylogeny of P. fluorescens and the phl cluster. It was determined that 2,4-DAPG production is an ancestral trait in the species P. fluorescens but that most lineages have lost this capacity through evolution. Furthermore, intragenomic recombination has relocated the phl cluster within the P. fluorescens genome at least three times, but the integrity of the cluster has always been maintained. The possible evolutionary and functional implications for retention of the phl cluster and 2,4-DAPG production in some lineages of P. fluorescens are discussed.
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