ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
Heritability of neurocognitive traits in familial schizophrenia.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.Schizophrenia bulletin · 2015Pooled it
- Differences in executive function among patients with schizophrenia, their unaffected first-degree relatives and healthy participants.The international journal of neuropsychopharmacology · 2020Article
- Long-term cognitive trajectories and heterogeneity in patients with schizophrenia and their unaffected siblings.Acta psychiatrica Scandinavica · 2018Article
- Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.International journal of molecular sciences · 2018Review
- Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.NeuroImage. Clinical · 2017Article
- A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient.Frontiers in psychiatry · 2017Review
- California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS).Schizophrenia research · 2015Article
- Genome-Wide Analyses of Working-Memory Ability: A Review.Current behavioral neuroscience reports · 2014Article
- Genetic complexity of episodic memory: a twin approach to studies of aging.Psychology and aging · 2014Article
- Sex differences in familiality effects on neurocognitive performance in schizophrenia.Biological psychiatry · 2013Article
- Performance on the Wisconsin Card Sorting Test in families of schizophrenia patients with different familial loadings.Schizophrenia bulletin · 2013Article
- An association study on the polymorphisms of dopaminergic genes with working memory in a healthy Chinese Han population.Cellular and molecular neurobiology · 2012Article
- Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.Brain : a journal of neurology · 2012Article
- Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS).Schizophrenia research · 2011Article
- Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report.Schizophrenia research · 2010Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
- Re: Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia.Schizophrenia research · 2010Article
Corrections and comments
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5 authors.
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Abstract
Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter-relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h(2) = 0.64-0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h(2) = 0.31-0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P < 0.0001) for all heritable variables. Bivariate analyses suggested that memory-IQ and visuomotor-processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition.
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