ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions.European journal of human genetics : EJHG · 2013Pooled it
- Meta-analysis of genome-wide association studies for personality.Molecular psychiatry · 2012Pooled it
- Article
- Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice.bioRxiv : the preprint server for biology · 2023Article
- Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.Addiction biology · 2019Article
- Neuregulin signaling pathway in smoking behavior.Translational psychiatry · 2017Article
- Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Smokescreen: a targeted genotyping array for addiction research.BMC genomics · 2016Article
- Nicotine withdrawal.Current topics in behavioral neurosciences · 2015Review
- Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.Brain research · 2013Article
- The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.Translational psychiatry · 2011Article
- A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.The American journal of psychiatry · 2011Article
- The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Nicotine withdrawal symptoms in adolescent and adult twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2010Article
- A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2010Article
- Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
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Authors and funding
20 authors at 6 institutions in 4 countries.
Funding
Abstract
Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores >1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and 11 at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW.
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