ArticleEuropean journal of immunology2009
Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex.
Article in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Chromatin remodeling in lymphocytic function and fate: the multifaceted roles of SWI/SNF complex.Frontiers in immunology · 2025Review
- Targeting RIPK1 kinase for modulating inflammation in human diseases.Frontiers in immunology · 2023Review
- SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation.Oncogene · 2022Article
- SMARCB1 Acts as a Quiescent Gatekeeper for Cell Cycle and Immune Response in Human Cells.International journal of molecular sciences · 2020Article
- smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish.Scientific reports · 2018Article
- The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.Experimental hematology · 2017Article
- Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.Frontiers in immunology · 2017Review
- ATP-dependent chromatin remodeling during mammalian development.Development (Cambridge, England) · 2016Review
- The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.BioMed research international · 2015Review
- LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting.BMC biology · 2012Article
- Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice.Biology of reproduction · 2012Article
- ATP-dependent chromatin remodeling in T cells.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2012Review
- The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.Current topics in microbiology and immunology · 2012Review
- Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements.Molecular and cellular biology · 2011Article
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.Cell research · 2011Review
- Chromatin remodeling complex NURF regulates thymocyte maturation.Genes & development · 2011Article
- Chromatin remodelling during development.Nature · 2010Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The Brg1/Brm-associated factor (BAF) chromatin remodeling complex directly binds the CD4 silencer and is essential for CD4 repression during T-cell development, because deletion of the ATPase subunit Brg1 or a dominant negative mutant of BAF57 each impairs CD4 repression in early thymocytes. Paradoxically, BAF57 is dispensable for remodeling nucleosomes in vitro or for binding of the BAF complex to the CD4 silencer in vivo. Thus, it is unclear whether BAF57-dependent CD4 repression involves chromatin remodeling and, if so, how the remodeling translates into CD4 repression. Here we show that nucleosomes at the CD4 silencer occupy multiple translational frames. BAF57 dominant negative mutant does not alter these frames, but reduces the accessibility of the entire silencer without affecting the flanking regions, concomitant with localized accumulation of linker histone H1 and eviction of Runx1, a key repressor of CD4 transcription that directly binds the CD4 silencer. Our data indicate that precise nucleosome positioning is not critical for the CD4 silencer function and that BAF57 participates in remodeling H1-containing chromatin at the CD4 silencer, which enables Runx1 to access the silencer and repress CD4. In addition to BAF57, multiple other subunits in the BAF complex are also dispensable for chromatin remodelling in vitro. Our data suggest that these subunits could also help remodel chromatin at a step after the recruitment of the BAF complex to target genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.