ArticleEuropean journal of immunology2009
A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection.
Article in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.Molecules (Basel, Switzerland) · 2019Article
- Calves Infected with Virulent and AttenuatedGenes · 2019Article
- Interleukin-17A Exacerbates Disease Severity in BALB/c Mice Susceptible to Lung Infection with Mycoplasma pulmonis.Infection and immunity · 2018Article
- The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection.Mediators of inflammation · 2018Review
- Anti-IL-17 therapy restricts and reverses late-term corneal allorejection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Protection against salmonella typhimurium, salmonella gallinarum, and salmonella enteritidis infection in layer chickens conferred by a live attenuated salmonella typhimurium strain.Immune network · 2015Article
- Toll-like receptor 2 promotes T helper 17 cells response in hepatitis B virus infection.International journal of clinical and experimental medicine · 2015Article
- Dysregulation in lung immunity - the protective and pathologic Th17 response in infection.European journal of immunology · 2013Review
- Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection.Molecular medicine (Cambridge, Mass.) · 2013Article
- The role of T helper (TH)17 cells as a double-edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic-induced immunomodulation.Clinical & developmental immunology · 2013Review
- Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection.BMC gastroenterology · 2012Article
- Vaccination of BALB/c mice with an avirulent Mycoplasma pneumoniae P30 mutant results in disease exacerbation upon challenge with a virulent strain.Infection and immunity · 2012Article
- Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.Gastroenterology · 2012Article
- Article
- Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control.Genes and immunity · 2011Article
- A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ production.European journal of immunology · 2010Article
- Interferon gamma and interleukin 4 have contrasting effects on immunopathology and the development of protective adaptive immunity against mycoplasma respiratory disease.The Journal of infectious diseases · 2010Article
- Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells.Infection and immunity · 2010Article
- Precarious balance: Th17 cells in host defense.Infection and immunity · 2010Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Immune responses to pathogens occur within the context of current and previous infections. Cross protection refers to the phenomena where infection with a particular pathogen provides enhanced resistance to a subsequent unrelated pathogen in an antigen-independent manner. Proposed mechanisms of antigen-independent cross protection have involved the secretion of IFN-gamma, which activates macrophages, thus providing enhanced innate immunity against the secondary viral or bacterial pathogen. Here we provide evidence that a primary infection with the chronic respiratory pathogen, Mycoplasma pulmonis, provides a novel form of cross protection against a secondary infection with Listeria monocytogenes that is not mediated by IFN-gamma, but instead relies upon IL-17 and mobilization of neutrophils. Mice infected with M. pulmonis have enhanced clearance of L. monocytogenes from the spleen and liver, which is associated with increased numbers of Gr-1(+)CD11b(+) cells and higher levels of IL-17. This enhanced clearance of L. monocytogenes was absent in mice depleted of Gr-1(+) cells or in mice deficient in the IL-17 receptor. Additionally, both the IL-17 receptor and neutrophils were essential for optimal clearance of M. pulmonis. Thus, a natural component of the immune response directed against M. pulmonis was able to enhance clearance of L. monocytogenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.