ReviewJournal of neurogenetics2009
Tolerance in Drosophila.
Review in Journal of neurogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- IntegratingFrontiers in pharmacology · 2025Article
- A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm inInternational journal of molecular sciences · 2024Review
- Pharmacological targeting of the GABAAddiction biology · 2020Article
- Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights fromJournal of experimental neuroscience · 2018Review
- Review
- Article
- The epigenetic landscape of alcoholism.International review of neurobiology · 2014Review
- Circadian genes differentially affect tolerance to ethanol in Drosophila.Alcoholism, clinical and experimental research · 2013Article
- Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Drosophila larvae as a model to study physiological alcohol dependence.Communicative & integrative biology · 2013Article
- Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance.PLoS genetics · 2013Article
- Ethanol preference in Drosophila melanogaster is driven by its caloric value.Alcoholism, clinical and experimental research · 2012Article
- Drosophila melanogaster as a model to study drug addiction.Human genetics · 2012Review
- A low concentration of ethanol impairs learning but not motor and sensory behavior in Drosophila larvae.PloS one · 2012Article
- Article
- A role for dynamin in triggering ethanol tolerance.Alcoholism, clinical and experimental research · 2012Article
- Tolerance to anesthesia depends on synaptic proteins.Behavior genetics · 2011Article
- Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila.Invertebrate neuroscience : IN · 2011Review
- Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence.International review of neurobiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The set of genes that underlie ethanol tolerance (inducible resistance) are likely to overlap with the set of genes responsible for ethanol addiction. Whereas addiction is difficult to recognize in simple model systems, behavioral tolerance is readily identifiable and can be induced in large populations of animals. Thus, tolerance lends itself to analysis in model systems with powerful genetics. Drosophila melanogaster has been used by a variety of laboratories for the identification of genes that interfere with the acquisition of ethanol tolerance. Here, I discuss the genes identified as being important for the production of ethanol tolerance in Drosophila. Some of these genes have also been shown to be important for the production of tolerance in mammals, demonstrating that gene discovery in Drosophila has predictive value for understanding the molecular pathways that generate tolerance in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.