ArticlePloS one2009
Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2021Pooled it
- Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries.BMC public health · 2015Pooled it
- Trial
- Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective againstFrontiers in immunology · 2024Article
- Incidence of MonomicrobialOpen forum infectious diseases · 2022Article
- Epidemiology, antimicrobial resistance and outcomes ofThe Lancet regional health. Western Pacific · 2022Article
- What Is the Optimal Follow-up Length for Mortality inOpen forum infectious diseases · 2022Article
- MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework.Frontiers in microbiology · 2022Review
- Prospective Validation of PREDICT and Its Impact on the Transesophageal Echocardiography Use in Management of Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: A prospective observational study (Ubon-sepsis).PLoS neglected tropical diseases · 2021Observational
- Impact of low blood culture usage on rates of antimicrobial resistance.The Journal of infection · 2021Article
- Review
- Evidence of the Practice of Self-Medication with Antibiotics among the Lay Public in Low- and Middle-Income Countries: A Scoping Review.Antibiotics (Basel, Switzerland) · 2020Article
- Anti-MRSA Activity of Actinomycin XFrontiers in microbiology · 2020Article
- [American journal of nuclear medicine and molecular imaging · 2020Article
- An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [EJNMMI research · 2019Article
- Cost-effectiveness of interventions to improve hand hygiene in healthcare workers in middle-income hospital settings: a model-based analysis.The Journal of hospital infection · 2018Article
- Article
- Clinical Epidemiology of Septic Arthritis Caused byThe American journal of tropical medicine and hygiene · 2017Article
- A cohort study of bacteremic pneumonia: The importance of antibiotic resistance and appropriate initial therapy?Medicine · 2016Observational
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundMost information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus infection in the tropics.
methodsA prospective, observational study of S. aureus bacteraemia was conducted in a 1000-bed regional hospital in northeast Thailand over 1 year. Detailed clinical data were collected and final outcomes determined at 12 weeks, and correlated with antimicrobial susceptibility profiles of infecting isolates. PRINCIPAL
findingsNinety-eight patients with S. aureus bacteraemia were recruited. The range of clinical manifestations was similar to that reported from temperate countries. The prevalence of endocarditis was 14%. The disease burden was highest at both extremes of age, whilst mortality increased with age. The all-cause mortality rate was 52%, with a mortality attributable to S. aureus of 44%. Methicillin-resistant S. aureus (MRSA) was responsible for 28% of infections, all of which were healthcare-associated. Mortality rates for MRSA and methicillin-susceptible S. aureus (MSSA) were 67% (18/27) and 46% (33/71), respectively (p = 0.11). MRSA isolates were multidrug resistant. Only vancomycin or fusidic acid would be suitable as empirical treatment options for suspected MRSA infection.
conclusionsS. aureus is a significant pathogen in northeast Thailand, with comparable clinical manifestations and a similar endocarditis prevalence but higher mortality than industrialised countries. S. aureus bacteraemia is frequently associated with exposure to healthcare settings with MRSA causing a considerable burden of disease. Further studies are required to define setting-specific strategies to reduce mortality from S. aureus bacteraemia, prevent MRSA transmission, and to define the burden of S. aureus disease and emergence of drug resistance throughout the developing world.
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