ArticlePloS one2009
Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Pubertal- and Stress-Dependent Changes in Cellular Activation and Expression of Excitatory Amino Acid Receptor Subunits in the Paraventricular Nucleus of the Hypothalamus in Male and Female Rats.Developmental neuroscience · 2025Article
- Epigenetic mechanism of SETDB1 in brain: implications for neuropsychiatric disorders.Translational psychiatry · 2020Review
- Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes.Neural plasticity · 2020Review
- Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Involvement of Nrf2 in development of anxiety-like behavior by linking Bcl2 to oxidative phosphorylation: estimation in rat hippocampus, amygdala, and prefrontal cortex.Journal of molecular neuroscience : MN · 2015Article
- Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.Trends in neurosciences · 2015Review
- The effects of stress on glutamatergic transmission in the brain.Molecular neurobiology · 2015Review
- Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?Frontiers in behavioral neuroscience · 2014Article
- Long-term occupational stress is associated with regional reductions in brain tissue volumes.PloS one · 2013Article
- Repeated Short-term (2h×14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice.Experimental neurobiology · 2012Article
- Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress.Neuropharmacology · 2012Review
- Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice.Journal of veterinary science · 2010Article
- Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus.Neuroscience · 2010Article
- Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids.Brain research · 2010Article
- Article
- Puberty, steroids and GABA(A) receptor plasticity.Psychoneuroendocrinology · 2009Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Kainate receptors are a class of ionotropic glutamate receptors that have a role in the modulation of glutamate release and synaptic plasticity in the hippocampal formation. Previous studies have implicated corticosteroids in the regulation of these receptors and recent clinical work has shown that polymorphisms in kainate receptor subunit genes are associated with susceptibility to major depression and response to anti-depressant treatment. In the present study we sought to examine the effects of chronic stress and corticosteroid treatments upon the expression of the mRNA of kainate receptor subunits GluR5-7 and KA1-2. Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6. 21 days of chronic restraint stress (CRS) elevated the expression of the KA1 subunit, but had no effect on the expression of the other subunits. Similarly, 21 days of treatment with a moderate dose of corticosterone also increased KA1 mRNA in the dentate gyrus, whereas a high corticosterone dose has no effect. Our results suggest an interaction between hippocampal kainate receptor composition and the hypothalamic-pituitary-adrenal (HPA) axis and show a selective chronic stress induced modulation of the KA1 subunit in the dentate gyrus and CA3 that has implications for stress-induced adaptive structural plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.