ArticleAmerican journal of hypertension2009
Predictors of first-fill adherence for patients with hypertension.
Article in American journal of hypertension, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Electronic Prescribing Compared to Paper-Based (Handwritten) Prescribing on Primary Medication Adherence in an Outpatient Setting: A Systematic Review.Applied clinical informatics · 2021Pooled it
- A randomized telephone intervention trial to reduce primary medication nonadherence.Journal of managed care & specialty pharmacy · 2015Trial
- Efficacy and safety of aliskiren and amlodipine combination therapy in patients with hypertension: a randomized, double-blind, multifactorial study.Journal of human hypertension · 2013Trial
- Not obtaining a medication the first time it is prescribed: primary non-adherence to cardiovascular pharmacotherapy.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Prevalence and predictors of primary nonadherence to medications prescribed in primary care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Combining patient reported outcomes and EHR data to understand population level treatment needs: correcting for selection bias in the migraine signature study.Journal of patient-reported outcomes · 2021Article
- Patient Support Program Increased Medication Adherence with Lower Total Health Care Costs Despite Increased Drug Spending.Journal of managed care & specialty pharmacy · 2019Article
- Participation in an innovative patient support program reduces prescription abandonment for adalimumab-treated patients in a commercial population.Patient preference and adherence · 2019Article
- Observational
- A Pilot Study Using a Web Survey to Identify Characteristics That Influence Hypogonadal Men to Initiate Testosterone Replacement Therapy.American journal of men's health · 2018Article
- Primary non-adherence and the new-user design.Pharmacoepidemiology and drug safety · 2018Article
- [Evaluation of primary adherence to medications in patients with chronic conditions: A retrospective cohort study].Atencion primaria · 2018Article
- Primary nonadherence to chronic disease medications: a meta-analysis.Patient preference and adherence · 2018Review
- Adherence to antihypertensive medications and associations with blood pressure among African Americans with hypertension in the Jackson Heart Study.Journal of the American Society of Hypertension : JASH · 2017Article
- Defining and Measuring Primary Medication Nonadherence: Development of a Quality Measure.Journal of managed care & specialty pharmacy · 2016Article
- Improving Patient's Primary Medication Adherence: The Value of Pharmaceutical Counseling.Medicine · 2015Article
- Primary non-adherence in Portugal: findings and implications.International journal of clinical pharmacy · 2015Article
- The evolving clinical management of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases.Medical care · 2013Article
- Untreated hypertension: prevalence and patient factors and beliefs associated with under-treatment in a population sample.Journal of human hypertension · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundBetween the promise of evidence-based medicine and the reality of inadequate patient outcomes lies patient adherence. Studies of prescription adherence have been hampered by methodologic problems. Most rely on patient self-report of adherence or cross-sectional data of plan-wide prescription fills to estimate patient-level adherence.
methodsWe conducted a retrospective cohort study and linked individual patient data for incident prescriptions for antihypertensive medications from electronic health records (EHRs) to claims data obtained from the patient's insurance plan. Clinical data were obtained from the Geisinger Clinic, a 41 site group practice serving central and northeastern Pennsylvania with an EHR in use since 2001. Adherence was defined as a prescription claim generated for the first-fill prescription within 30 days of the prescribing date.
resultsOf the 3,240 patients written a new, first-time prescription for an antihypertensive medication, 2,685 (83%) generated a corresponding claim within 30 days. Sex, age, therapeutic class, number of other medications prescribed within 10 days of the antihypertensive prescription, number of refills, co-pay, comorbidity score, baseline blood pressure (BP), and change in BP were significantly associated with first-fill rates (P < 0.05).
conclusionsPatients who are older, female, have multiple comorbidities, and/or have relatively lower BPs may be less likely to fill a first prescription for antihypertensive medications and may be potential candidates for interventions to improve adherence to first-fill prescriptions.
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