ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Small molecule inhibitors of divalent metal transporter-1.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- In vivo silencing of intestinal DMT1 mitigates iron loading in β-thalassemia intermedia (Hbbth3/+) mice.Blood advances · 2024Article
- Managing Iron Overload: A Gut Check.The Journal of pharmacology and experimental therapeutics · 2023Article
- Article
- Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Zinc ions have a potential to attenuate both Ni ion uptake and Ni ion-induced inflammation.Scientific reports · 2018Article
- Targeting iron metabolism in drug discovery and delivery.Nature reviews. Drug discovery · 2017Review
- Regulation of divalent metal transporter-1 by serine phosphorylation.The Biochemical journal · 2016Article
- The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways.Molecular biology reports · 2014Review
- Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Pharmacology of iron transport.Annual review of pharmacology and toxicology · 2013Review
- Article
- Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro.The Journal of biological chemistry · 2012Article
- H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics.Current topics in membranes · 2012Review
- Anticancer activity of the iron facilitator LS081.Journal of experimental & clinical cancer research : CR · 2011Article
- Human iron transporters.Genes & nutrition · 2011Article
- Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial.Journal of materials science. Materials in medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Divalent metal transporter-1 (DMT1) is a divalent cation transporter that plays a key role in iron metabolism by mediating ferrous iron uptake across the small intestine. We have previously identified several small molecule inhibitors of iron uptake (4). Using a cell line that stably overexpresses DMT1, we screened the ability of these inhibitors to specifically block this transporter's activity. One compound, NSC306711, inhibited DMT1-mediated iron uptake in a reversible and competitive manner. This inhibitor is a polysulfonated dye containing two copper centers. Although one of these two sites could be chelated by Triethylenetetramine copper chelation did not perturb NSC306711 inhibition of DMT1 activity. Several other polysulfonated dyes with structural features similar to NSC306711 were identified as potential DMT1 transport inhibitors. This study characterizes important pharmacological tools that can be used to probe DMT1's mechanism of iron transport and its role in iron metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.