ArticleJournal of leukocyte biology2009
Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo.
Article in Journal of leukocyte biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
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- Exploring the possible use of saponin adjuvants in COVID-19 vaccine.Human vaccines & immunotherapeutics · 2020Review
- CpG Oligonucleotides Protect Mice From Alphavirus Encephalitis: Role of NK Cells, Interferons, and TNF.Frontiers in immunology · 2020Article
- Potential Inherent Stimulation of the Innate Immune System by Nucleic Acid Aptamers and Possible Corrective Approaches.Pharmaceuticals (Basel, Switzerland) · 2018Review
- TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Harnessing RNA sequencing for global, unbiased evaluation of two new adjuvants for dendritic-cell immunotherapy.Oncotarget · 2017Article
- IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation.European journal of immunology · 2016Article
- Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG.Immunology · 2015Article
- Cross talk of the first-line defense TLRs with PI3K/Akt pathway, in preconditioning therapeutic approach.Molecular and cellular therapies · 2015Article
- Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1.Mediators of inflammation · 2015Article
- Preconditioning with intravenous colitic cell-free DNA prevents DSS-colitis by altering TLR9-associated gene expression profile.Digestive diseases and sciences · 2014Article
- The impact of "omic" and imaging technologies on assessing the host immune response to biodefence agents.Journal of immunology research · 2014Review
- TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.Cancer research · 2013Article
- Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.TheScientificWorldJournal · 2013Article
- Mechanisms of action of adjuvants.Frontiers in immunology · 2013Article
- Toll-like receptors and opportunities for new sepsis therapeutics.Current infectious disease reports · 2012Article
- Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA.Journal of leukocyte biology · 2012Article
- The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy.Respiratory research · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Bacterial DNA expressing unmethylated CpG motifs binds to TLR9, thereby stimulating a broadly protective, innate immune response. Although CpG-mediated signal transduction has been studied, the scope of TLR9-dependent gene expression is incompletely understood. To resolve these issues, mice were treated with immunostimulatory CpG oligonucleotides (ODN) and splenic mRNA levels monitored from 30 min through 3 days by microarray. Through the unique application of bioinformatic analysis to these experimental data, this study is the first to describe the complex regulatory networks responsible for TLR9-mediated gene expression. Current results are the first to establish that CpG-induced stimulation of the innate immune system proceeds in multiple waves over time, and gene up-regulation is mediated by a small number of temporally activated "major inducers" and "minor inducers". An additional study of TNF knockout mice supports the conclusion that the regulatory networks identified by our bioinformatic analysis accurately identified CpG ODN-driven gene-gene interactions in vivo. Equally important, this work identifies the counter-regulatory mechanisms embedded within the signaling cascade that suppresses the proinflammatory response triggered in vivo by CpG DNA stimulation. Identifying these network interactions provides novel and global insights into the regulation of TLR9-mediated gene activation, improves our understanding of TLR-mediated host defense, and facilitates the development of interventions designed to optimize the nature and duration of the ensuing response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.