ArticleInfection and immunity2009
Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- NinoaPathogens (Basel, Switzerland) · 2024Article
- Article
- Central nervous system commitment in Chagas disease.Frontiers in immunology · 2022Review
- Mechanisms Associated withLife (Basel, Switzerland) · 2021Review
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
- Parasite-derived neurotrophic factor/trans-sialidase of Trypanosoma cruzi links neurotrophic signaling to cardiac innate immune response.Infection and immunity · 2014Article
- Sympathetic glial cells and macrophages develop different responses to Trypanosoma cruzi infection or lipopolysaccharide stimulation.Memorias do Instituto Oswaldo Cruz · 2014Article
- Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress.Cellular microbiology · 2013Article
- Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA.PloS one · 2013Article
- Multigene families in Trypanosoma cruzi and their role in infectivity.Infection and immunity · 2012Review
- Mechanisms of Trypanosoma cruzi persistence in Chagas disease.Cellular microbiology · 2012Review
- Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.Infection and immunity · 2011Article
- Trypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection.Journal of neuroparasitology · 2010Article
- Autoantibodies to neurotrophic receptors TrkA, TrkB and TrkC in patients with acute Chagas' disease.Scandinavian journal of immunology · 2010Article
- Review on Trypanosoma cruzi: Host Cell Interaction.International journal of cell biology · 2010Article
- Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy.Science signaling · 2009Article
- Neurochagas: Experimental and human literature of an uncommon entity (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Trypanosoma cruzi, the agent of Chagas' disease, promotes neuron survival through receptor tyrosine kinase TrkA and glycosylphosphatidylinositol-anchored glial cell-derived family ligand receptors (GFRalpha). However, these receptors are expressed by only a subset of neurons and at low levels or not at all in glial cells. Thus, T. cruzi might exploit an additional neurotrophic receptor(s) to maximize host-parasite equilibrium in the nervous system. We show here that T. cruzi binds TrkC, a neurotrophic receptor expressed by glial cells and many types of neurons, and that the binding is specifically inhibited by neurotrophin-3, the natural TrkC ligand. Coimmunoprecipitation and competition assays show that the trans-sialidase/parasite-derived neurotrophic factor (PDNF), previously identified as a TrkA ligand, mediates the T. cruzi-TrkC interaction. PDNF promotes TrkC-dependent mitogen-activated protein kinase signaling, neurite outgrowth, and survival of genetically engineered PC12 neuronal cells and glial Schwann cells in a TrkC-dependent manner. Thus, TrkC is a new neurotrophic receptor that T. cruzi engages to promote the survival of neuronal and glial cells. The results raise the possibility that T. cruzi recognition of TrkC underlies regenerative events in nervous tissues of patients with Chagas' disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.