ArticleThe Journal of biological chemistry2009
Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Dopaminergic Modulation of Prefrontal Cortex Inhibition.Biomedicines · 2023Review
- Review
- Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission.Schizophrenia bulletin · 2019Article
- Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus.Scientific reports · 2017Article
- Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex.Brain research · 2016Review
- Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex.The Journal of physiology · 2016Article
- Distinct Physiological Effects of Dopamine D4 Receptors on Prefrontal Cortical Pyramidal Neurons and Fast-Spiking Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Synapse-specific contributions in the cortical pathology of schizophrenia.Neurobiology of disease · 2013Review
- Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures.ISRN neurology · 2013Article
- Dopamine, cognitive function, and gamma oscillations: role of D4 receptors.Frontiers in cellular neuroscience · 2013Article
- Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease.The Journal of physiology · 2012Article
- Review
- Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dopamine D4 receptor activation increases hippocampal gamma oscillations by enhancing synchronization of fast-spiking interneurons.PloS one · 2012Article
- Dopamine receptor type 5 in the primary cilia has dual chemo- and mechano-sensory roles.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Leukemia inhibitory factor regulates trafficking of T-type Ca2+ channels.American journal of physiology. Cell physiology · 2011Article
- The roles of the actin cytoskeleton in fear memory formation.Frontiers in behavioral neuroscience · 2011Article
- The dopamine D4 receptor: biochemical and signalling properties.Cellular and molecular life sciences : CMLS · 2010Review
- Dopamine-dependent tuning of striatal inhibitory synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The GABA(A) receptor-mediated inhibitory transmission in prefrontal cortex (PFC) is implicated in cognitive processes such as working memory. Our previous study has found that GABA(A)R current is subject to the regulation of dopamine D(4) receptors, a PFC-enriched neuromodulator critically involved in various mental disorders associated with PFC dysfunction. In this study, we have investigated the cellular mechanism underlying D(4) modulation of GABA(A)Rs. We found that the density of surface clusters of GABA(A)R beta2/3 subunits was reduced by D(4), suggesting that the D(4) reduction of GABA(A)R current is associated with a decrease in functional GABA(A)Rs at the plasma membrane. Moreover, the D(4) reduction of GABA(A)R current was blocked by the actin stabilizer phalloidin and was occluded by the actin destabilizer latrunculin, suggesting that D(4) regulates GABA(A)R trafficking via an actin-dependent mechanism. Cofilin, a major actin depolymerizing factor whose activity is strongly increased by dephosphorylation at Ser(3), provides the possible link between D(4) signaling and the actin dynamics. Because myosin motor proteins are important for the transport of vesicles along actin filaments, we also tested the potential involvement of myosin in D(4) regulation of GABA(A)R trafficking. We found that dialysis with a myosin peptide, which competes with endogenous myosin proteins for actin-binding sites, prevented the D(4) reduction of GABA(A)R current. These results suggest that D(4) receptor activation increases cofilin activity presumably via its dephosphorylation, resulting in actin depolymerization, thus causing a decrease in the myosin-based transport of GABA(A)R clusters to the surface.
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