ArticleProceedings of the National Academy of Sciences of the United States of America2009
Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Natural killer T cells as therapeutic targets for neuroinflammatory disorders.Animal cells and systems · 2026Review
- Natural Killer T Cell Diversity and Immunotherapy.Cancers · 2023Review
- Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Invariant Natural Killer T-Cells and Total CD1d Restricted Cells Differentially Influence Lipid Metabolism and Atherosclerosis in Low Density Receptor Deficient Mice.International journal of molecular sciences · 2019Article
- Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients.Frontiers in immunology · 2019Article
- Natural killer T cells in atherosclerosis.Nature reviews. Cardiology · 2017Review
- The processing and presentation of lipids and glycolipids to the immune system.Immunological reviews · 2016Review
- Role of Group 1 CD1-Restricted T Cells in Infectious Disease.Frontiers in immunology · 2015Review
- Nonclassical T cells and their antigens in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Lipid antigens in immunity.Biological chemistry · 2014Review
- Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The functions of type I and type II natural killer T cells in inflammatory bowel diseases.Inflammatory bowel diseases · 2013Review
- Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.Nature immunology · 2012Article
- Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type.Genes and immunity · 2012Article
- Natural killer T cells in lipoprotein metabolism and atherosclerosis.Thrombosis and haemostasis · 2011Review
- Natural killer T cells in health and disease.Frontiers in bioscience (Scholar edition) · 2011Review
- Article
- Structural basis for lipid-antigen recognition in avian immunity.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- How do natural killer T cells help B cells?Expert review of vaccines · 2009Review
- Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides.OncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Valpha14i) and type II (non-Valpha14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.