ReviewJournal of bioenergetics and biomembranes1991
Calcium-activated potassium channels: regulation by calcium.
Review in Journal of bioenergetics and biomembranes, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 261 citations in OpenAlex.
- Special Issue "Ion Conductance and Ion Regulation in Human Health and Disease".International journal of molecular sciences · 2025Article
- Single-cell transcriptomic analysis reveals genome evolution in predatory litostomatean ciliates.European journal of protistology · 2024Article
- Calcium-gated potassium channel blockade via membrane-facing fenestrations.Nature chemical biology · 2024Article
- Ion channels as a therapeutic target for renal fibrosis.Frontiers in physiology · 2022Review
- Energy imbalance alters CaeLife · 2017Article
- Naringenin inhibits pacemaking activity in interstitial cells of Cajal from murine small intestine.Integrative medicine research · 2017Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Methamphetamine Regulation of Firing Activity of Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Characteristics of single large-conductance Ca2+-activated K+ channels and their regulation of action potentials and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus.American journal of physiology. Cell physiology · 2014Article
- Effects of aerobic exercise training on large-conductance Ca(2+)-activated K (+) channels in rat cerebral artery smooth muscle cells.European journal of applied physiology · 2013Article
- Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells.Frontiers in behavioral neuroscience · 2013Article
- KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.The Journal of biological chemistry · 2012Article
- Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.Journal of toxicology · 2012Article
- Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes.PloS one · 2011Article
- The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy.Neuroscience research · 2011Article
- Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes.American journal of physiology. Cell physiology · 2010Article
- Intersubunit coupling in the pore of BK channels.The Journal of biological chemistry · 2009Article
- Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.The Journal of pharmacology and experimental therapeutics · 2009Article
- Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary.Reproductive biology and endocrinology : RB&E · 2009Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of calcium-activated K channels has been described and can be conveniently separated into three classes based on differences in single-channel conductance, voltage dependence of channel opening, and sensitivity to blockers. Large-conductance calcium-activated K channels typically require micromolar concentrations of calcium to open, and their sensitivity to calcium increases with membrane depolarization, suggesting that they may be involved in repolarization events. Small-conductance calcium-activated K channels are generally more sensitive to calcium at negative membrane potentials, but their sensitivity to calcium is independent of membrane potential, suggesting that they may be involved in regulating membrane properties near the resting potential. Intermediate-conductance calcium-activated K channels are a loosely defined group, where membership is determined because a channel does not fit in either of the other two groups. Within each broad group, variations in calcium sensitivity and single-channel conductance have been observed, suggesting that there may be families of closely related calcium-activated K channels. Kinetic studies of the gating of calcium-activated potassium channels have revealed some basic features of the mechanisms involved in activation of these channels by calcium, including the number of calcium ions participating in channel opening, the number of major conformations of the channels involved in the gating process, and the number of transition pathways between open and closed states. Methods of analysis have been developed that may allow identification of models that give accurate descriptions of the gating of these channels. Although such kinetic models are likely to be oversimplifications of the behavior of a large macromolecule, these models may provide some insight into the mechanisms that control the gating of the channel, and are subject to falsification by new data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.