ArticleJournal of the neurological sciences2009
Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study.
Article in Journal of the neurological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.Nature reviews. Neurology · 2015Guideline
- Optimized T1-MPRAGE sequence for better visualization of spinal cord multiple sclerosis lesions at 3T.AJNR. American journal of neuroradiologyTrial
- Spinal cord imaging in multiple sclerosis: from diagnosis to disease progression.Journal of neurology · 2026Review
- MEASURING IMPACT OF SUPER-RESOLUTION ON SPINAL CORD MRI SCANS: LESION DETECTION SENSITIVITY, VARIABILITY, AND CLINICAL IMPACT.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spinal cord lesions in relapsing-remitting multiple sclerosis: Prognostic value of intrathecal production of immunoglobulins.PloS one · 2025Article
- Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study.CNS drugs · 2024Article
- Evaluating noninvasive brain stimulation to treat overactive bladder in individuals with multiple sclerosis: a randomized controlled trial protocol.BMC urology · 2024Article
- Article
- Imaging of the Spinal Cord in Multiple Sclerosis: Past, Present, Future.Brain sciences · 2020Review
- Magnetic resonance imaging in immune-mediated myelopathies.Journal of neurology · 2020Review
- Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.Brain : a journal of neurology · 2019Article
- Additive Effect of Spinal Cord Volume, Diffuse and Focal Cord Pathology on Disability in Multiple Sclerosis.Frontiers in neurology · 2019Article
- Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis.eNeurologicalSci · 2018Article
- Clinical Utility of a Novel Ultrafast T2-Weighted Sequence for Spine Imaging.AJNR. American journal of neuroradiology · 2018Article
- Magnetic Resonance Imaging in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2018Review
- Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1-Mechanisms, Efficacy, and Safety.AJNR. American journal of neuroradiology · 2017Review
- MRI in the assessment and monitoring of multiple sclerosis: an update on best practice.Therapeutic advances in neurological disorders · 2017Review
- The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis.BMC medical imaging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAssess the relationship between spinal cord T2 hyperintense lesions and clinical status in multiple sclerosis (MS) with 1.5 and 3 T MRI.
methodsWhole cord T2-weighted fast spin-echo MRI was performed in 32 MS patients [Expanded Disability Status Scale (EDSS) score (mean+/-SD: 2+/-1.9), range 0-6.5]. Protocols at 1.5 T and 3 T were optimized and matched on voxel size.
resultsModerate correlations were found between whole cord lesion volume and EDSS score at 1.5 T (r(s)=.36, p=0.04), but not at 3 T (r(s)=0.13, p=0.46). Pyramidal Functional System Score (FSS) correlated with thoracic T2 lesion number (r(s)=.46, p=0.01) and total spinal cord lesion number (r(s)=0.37, p=0.04) and volume (r(s)=0.37, p=0.04) at 1.5 T. Bowel/bladder FSS correlated with T2 lesion volume and number in the cervical, thoracic, and total spine at 1.5 T (r(s) 0.40-0.57, all p<0.05). These MRI-FSS correlations were non-significant at 3 T. However, these correlation coefficients did not differ significantly between platforms (Choi's test p>0.05). Correlations between whole cord lesion volume and timed 25-foot walk were non-significant at 1.5 T and 3 T (p>0.05). Lesion number and volume did not differ between MRI platforms in the MS group (p>0.05).
conclusionsDespite the use of higher field MRI strength, the link between spinal lesions and MS disability remains weak. The 1.5 T and 3 T protocols yielded similar results for many comparisons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.