ArticleBiology of reproduction2009
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.
Article in Biology of reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.Cell & bioscience · 2026Article
- Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Two acquired mouse Y chromosome-linked genes, Prssly and Teyorf1, are dispensable for male fertility‡.Biology of reproduction · 2022Article
- Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.BMC biology · 2021Article
- Testicular germ cell-specific lncRNA,Science advances · 2021Article
- Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.Molecular biology and evolution · 2020Article
- Genomic Structure, Evolutionary Origins, and Reproductive Function of a Large Amplified Intrinsically Disordered Protein-Coding Gene on the X Chromosome (G3 (Bethesda, Md.) · 2020Article
- Differential Sperm Motility Mediates the Sex Ratio Drive Shaping Mouse Sex Chromosome Evolution.Current biology : CB · 2019Article
- Article
- Rescue ofGenes · 2019Article
- Systematic quantitative analysis of H2A and H2B variants by targeted proteomics.Epigenetics & chromatin · 2018Article
- EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.Molecular and cellular biology · 2017Article
- SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.Cell death and differentiation · 2017Article
- Evolutionary history of the mammalian synaptonemal complex.Chromosoma · 2016Review
- Expression and epigenomic landscape of the sex chromosomes in mouse post-meiotic male germ cells.Epigenetics & chromatin · 2016Article
- Functional significance of the sex chromosomes during spermatogenesis.Reproduction (Cambridge, England) · 2015Review
- Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels.BMC research notes · 2015Article
- Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.Genome biology · 2015Article
- Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Deletion analysis has established that genes on the Y chromosome are essential for normal sperm production in humans, mice, and Drosophila. In mice, long-arm deletions have an impact on spermiogenesis, with the most extensive deletions resulting in severe sperm head malformations and infertility. Intriguingly, smaller deletions are compatible with fertility but result in a distorted sex ratio in favor of females, and recently it was found that Y long-arm deletions are also associated with a marked upregulation of several X-encoded and Y-encoded spermatid-expressed genes. The mouse Y long arm encodes a number of distinct transcripts, each of which derives from multiple gene copies. Of these multicopy genes, the recently described Sly has been favored as the gene underlying the spermiogenic defects associated with Y long-arm deletions. To assess the candidacy of Sly, the expression of this gene was examined in the testis at the transcript and protein levels. Sly is transcribed after the first meiotic division in secondary spermatocytes and round spermatids and encodes two transcript variants, Sly_v1 and Sly_v2 (proteins referred to as SLY1 and SLY2). We raised an antibody against SLY1 which detected the protein in round and early elongating spermatids, where it is predominantly cytoplasmic. Yeast two-hybrid and coimmunoprecipitation studies demonstrated that SLY1 interacts with the acrosomal protein DKKL1, the histone acetyltransferase KAT5 (also known as TIP60), and the microtubule-associated protein APPBP2. Together, these data suggest SLY1 may be involved in multiple processes during spermiogenesis, including the control of gene expression and the development or function of the acrosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.