ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- Functional organization of vestibulospinal inputs responsible for tail postural control in larvalFrontiers in neurology · 2024Article
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dopamine: a parallel pathway for the modulation of spinal locomotor networks.Frontiers in neural circuits · 2014Review
- Multiple monoaminergic modulation of posturo-locomotor network activity in the newborn rat spinal cord.Frontiers in neural circuits · 2014Article
- Convergent rhythm generation from divergent cellular mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The same core rhythm generator underlies different rhythmic motor patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord.Frontiers in neural circuits · 2010Article
- Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biogenic amines serotonin (5-HT) and noradrenaline (NA) are well known modulators of central pattern-generating networks responsible for vertebrate locomotion. Here we have explored monoaminergic modulation of the spinal circuits that generate two distinct modes of locomotion in the metamorphosing frog Xenopus laevis. At metamorphic climax when propulsion is achieved by undulatory larval tail movements and/or by kicking of the newly developed adult hindlimbs, the underlying motor networks remain spontaneously active in vitro, producing either separate fast axial and slow appendicular rhythms or a single combined rhythm that drives coordinated tail-based and limb-based swimming in vivo. In isolated spinal cords already expressing distinct axial and limb rhythms, bath-applied 5-HT induced coupled network activity through an opposite slowing of axial rhythmicity (by increasing motoneuron burst and cycle durations) and an acceleration of limb rhythmicity (by decreasing burst and cycle durations). In contrast, in preparations spontaneously expressing coordinated fictive locomotion, exogenous NA caused a dissociation of spinal activity into separate faster axial and slower appendicular rhythms by decreasing and increasing burst and cycle durations, respectively. Moreover, in preparations from premetamorphic and postmetamorphic animals that express exclusively axial-based or limb-based locomotion, 5-HT and NA modified the developmentally independent rhythms in a similar manner to the amines' opposing effects on the coexisting circuits at metamorphic climax. Thus, by exerting differential modulatory actions on one network that are opposite to their influences on a second adjacent circuit, these two amines are able to precisely regulate the functional relationship between different rhythmogenic networks in a developing vertebrate's spinal cord.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.