ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The contribution of synaptic inputs to sustained depolarizations in reticulospinal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 40 citations in OpenAlex.
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- A Brainstem Neural Substrate for Stopping Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Brainstem Steering of Locomotor Activity in the Newborn Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Swimming rhythm generation in the caudal hindbrain of the lamprey.Journal of neurophysiology · 2018Article
- Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.Journal of neurophysiology · 2017Article
- The mesencephalic locomotor region sends a bilateral glutamatergic drive to hindbrain reticulospinal neurons in a tetrapod.The Journal of comparative neurology · 2016Article
- Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.Frontiers in neural circuits · 2016Review
- Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats.Neurochemical research · 2015Article
- Article
- Gating of steering signals through phasic modulation of reticulospinal neurons during locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Modulation of circuit feedback specifies motor circuit output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Specific neural substrate linking respiration to locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Spinal locomotor inputs to individually identified reticulospinal neurons in the lamprey.Journal of neurophysiology · 2011Article
- Gastric and pyloric motor pattern control by a modulatory projection neuron in the intact crab Cancer pagurus.Journal of neurophysiology · 2011Article
- Neuronal control of swimming behavior: comparison of vertebrate and invertebrate model systems.Progress in neurobiology · 2011Review
- Defining the excitatory neurons that drive the locomotor rhythm in a simple vertebrate: insights into the origin of reticulospinal control.The Journal of physiology · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory stimulation elicits sustained depolarizations in lamprey reticulospinal (RS) cells for which intrinsic properties were shown to play a crucial role. The depolarizations last up to minutes, and we tested whether the intrinsic properties required the cooperation of synaptic inputs to maintain RS cells depolarized for such long periods of time. Ascending spinal inputs to RS cells were reversibly blocked by applying xylocaine over the rostral spinal cord segments. The duration of the sustained depolarizations was markedly reduced. The membrane potential oscillations in tune with locomotor activity that were present under control condition were also abolished. The contribution of excitatory glutamatergic inputs was then assessed by applying CNQX and AP-5 over one of two simultaneously recorded homologous RS cells on each side of the brainstem. The level of sensory-evoked depolarization decreased significantly in the cell exposed to the antagonists compared with the other RS cell monitored as a control. In contrast, local application of glycine only produced a transient membrane potential hyperpolarization with a marked reduction in the amplitude of membrane potential oscillations. Locally applied strychnine did not change the duration of the sustained depolarizations, suggesting that mechanisms other than glycinergic inhibition are involved in ending the sustained depolarizations in RS cells. It is concluded that excitatory glutamatergic inputs, including ascending spinal feedback, cooperate with intrinsic properties of RS cells to maintain the cells depolarized for prolonged periods, sustaining long bouts of escape swimming.
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