ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Early-stage waves in the retinal network emerge close to a critical state transition between local and global functional connectivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 85 citations in OpenAlex.
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- A Self-Similarity Logic May Shape the Organization of the Nervous System.Advances in neurobiology · 2024Article
- Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias.Scientific reports · 2023Article
- Dystrophin Is Required for the Proper Timing in Retinal Histogenesis: A Thorough Investigation on theFrontiers in neuroscience · 2020Article
- Neural field models for latent state inference: Application to large-scale neuronal recordings.PLoS computational biology · 2019Article
- A biophysical model explains the spontaneous bursting behavior in the developing retina.Scientific reports · 2019Article
- Theoretical Models of Neural Development.iScience · 2018Review
- Article
- Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Developmental time windows for axon growth influence neuronal network topology.Biological cybernetics · 2015Article
- A reaction-diffusion model of cholinergic retinal waves.PLoS computational biology · 2014Article
- Copper is an endogenous modulator of neural circuit spontaneous activity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- MicroRNAs in neuronal communication.Molecular neurobiology · 2014Review
- Slow feature analysis on retinal waves leads to V1 complex cells.PLoS computational biology · 2014Article
- Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.The Journal of physiology · 2014Article
- Review
- A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.Journal of neurophysiology · 2013Article
- Hyperpolarization of resting membrane potential causes retraction of spontaneous Ca(i)²⁺ transients during mouse embryonic circuit development.The Journal of physiology · 2013Article
- Cellular mechanisms underlying spatiotemporal features of cholinergic retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A novel, biophysically realistic model for early-stage, acetylcholine-mediated retinal waves is presented. In this model, neural excitability is regulated through a slow after-hyperpolarization (sAHP) operating on two different temporal scales. As a result, the simulated network exhibits competition between a desynchronizing effect of spontaneous, cell-intrinsic bursts, and the synchronizing effect of synaptic transmission during retinal waves. Cell-intrinsic bursts decouple the retinal network through activation of the sAHP current, and we show that the network is capable of operating at a transition point between purely local and global functional connectedness, which corresponds to a percolation phase transition. Multielectrode array recordings show that, at this point, the properties of retinal waves are reliably predicted by the model. These results indicate that early spontaneous activity in the developing retina is regulated according to a very specific principle, which maximizes randomness and variability in the resulting activity patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.