ArticleCerebral cortex (New York, N.Y. : 1991)2009
Glutamatergic inhibition in sensory neocortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Network resonance and the auditory steady state response.Scientific reports · 2024Article
- Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks.Nature communications · 2021Article
- Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future.Journal of Alzheimer's disease : JAD · 2020Review
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Somatostatin depresses the excitability of subicular bursting cells: Roles of inward rectifier KHippocampus · 2017Article
- Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway.Brain sciences · 2017Review
- Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells.Frontiers in cellular neuroscience · 2017Article
- Article
- Thalamus plays a central role in ongoing cortical functioning.Nature neuroscience · 2016Review
- Depression of neuronal excitability and epileptic activities by group II metabotropic glutamate receptors in the medial entorhinal cortex.Hippocampus · 2015Article
- Developmental decline in modulation of glutamatergic synapses in layer IV of the barrel cortex by group II metabotropic glutamate receptors.Neuroscience · 2015Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Differential expression of mGluR2 in the developing cerebral cortex of the mouse.Journal of biomedical science and engineering · 2014Article
- Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex.Journal of neurophysiology · 2014Article
- The function of metabotropic glutamate receptors in thalamus and cortex.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Cortical connectivity and sensory coding.Nature · 2013Review
- Functional convergence of thalamic and intrinsic projections to cortical layers 4 and 6.Neurophysiology · 2013Article
- Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the mammalian brain, glutamate and gamma-aminobutyric acid are considered major excitatory and inhibitory neurotransmitters, respectively. However, we have found evidence that glutamate can also act as a postsynaptic inhibitory neurotransmitter in layer 4 of the neocortex. Using whole-cell recordings from layer 4 neurons in slice preparations from the mouse visual, auditory, and somatosensory cortices, we found that metabotropic glutamate receptor (mGluR) agonists (ACPD, APDC, and DCG IV) elicit a robust, long-lasting hyperpolarization that is abolished by the group II mGluR antagonist, MCCG. This response largely involves a K(+) conductance mediated by G-protein activity and GIRK channels. Furthermore, electrical and photostimulation of the intracortical inputs to layer 4 elicits a similar hyperpolarization that is blocked by group II mGluR antagonists. This novel inhibition mediated by group II mGluRs may be an unappreciated mechanism for refining cortical receptive fields in layer 4 and may enable synaptic gain control during periods of high activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.