ArticleJournal of neurophysiology2009
Cortically activated interneurons shape spatial aspects of cortico-accumbens processing.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens.bioRxiv : the preprint server for biology · 2026Article
- The medial orbitofrontal cortex governs reward-related circuits in an age-dependent manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.Nature communications · 2021Article
- Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons.Addiction biology · 2017Article
- Kappa Opioid Receptors Mediate Heterosynaptic Suppression of Hippocampal Inputs in the Rat Ventral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram.Frontiers in pharmacology · 2017Article
- Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration.Brain research · 2016Article
- Olanzapine Treatment of Adolescent Rats Alters Adult D2 Modulation of Cortical Inputs to the Ventral Striatum.The international journal of neuropsychopharmacology · 2016Article
- Cortical drive of low-frequency oscillations in the human nucleus accumbens during action selection.Journal of neurophysiology · 2015Article
- Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex.Biological psychiatry · 2015Article
- Time-dependent decreases in nucleus accumbens AMPA/NMDA ratio and incubation of sucrose craving in adolescent and adult rats.Psychopharmacology · 2014Article
- An elemental model of retrospective revaluation without within-compound associations.Learning & behavior · 2014Article
- Closing the gate in the limbic striatum: prefrontal suppression of hippocampal and thalamic inputs.Neuron · 2013Article
- Article
- Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.Frontiers in cellular neuroscience · 2013Article
- Cannabinoid receptor 1-expressing neurons in the nucleus accumbens.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Distinct prefrontal cortical regions negatively regulate evoked activity in nucleus accumbens subregions.The international journal of neuropsychopharmacology · 2012Article
- Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior.Frontiers in behavioral neuroscience · 2012Article
- Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Enhanced high-frequency membrane potential fluctuations control spike output in striatal fast-spiking interneurones in vivo.The Journal of physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Basal ganglia circuits are organized as parallel loops that have been proposed to compete in a winner-take-all fashion to determine the appropriate behavioral outcome. However, limited experimental support for strong lateral inhibition mechanisms within striatal regions questions this model. Here, stimulation of the prefrontal cortex (PFC) using naturally occurring bursty patterns inhibited firing in most nucleus accumbens (NA) projection neurons. When an excitatory response was observed for one stimulation site, neighboring PFC sites evoked inhibition in the same neuron. Furthermore, PFC stimulation activated interneurons, and PFC-evoked inhibition was blocked by GABA(A) antagonists in corticoaccumbens slice preparations. Thus bursting PFC activity recruits local inhibition in the NA, shaping responses of projection neurons with a topographical arrangement that allows inhibition among parallel corticoaccumbens channels. The data indicate a high order of information processing within striatal circuits that should be considered in models of basal ganglia function and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.