Trial reportJPEN. Journal of parenteral and enteral nutrition
Ghrelin does not predict adaptive hyperphagia in patients with short bowel syndrome.
Trial report in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Fecal microbiota transplantation in a rodent model of short bowel syndrome: A therapeutic approach?Frontiers in cellular and infection microbiology · 2023Article
- Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition.Frontiers in nutrition · 2022Article
- Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome.Scientific reports · 2016Article
- Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome.Microorganisms · 2016Review
- Intestinal mucosal atrophy and adaptation.World journal of gastroenterology · 2012Review
- Gastric bypass reversal in patients with short bowel syndrome.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdaptive hyperphagia is associated with reduced dependence on parenteral nutrition in patients with short bowel syndrome, but mechanisms have not been described. Ghrelin (GHR) has orexigenic effects, whereas peptide YY (PYY) reduces intake. GHR also acts as a hormone to control body fat stores. The authors evaluated whether GHR or PYY was related to caloric intake or absorption in patients with short bowel syndrome and whether GHR was associated with body mass index.
methodsPatients were admitted twice for nutrient balance. Height and body weight were obtained using standardized protocols. Energy intake > 40 kcal/kg/day was defined as adaptive hyperphagia. Fasting plasma PYY and GHR were assayed in duplicate with Linco enzyme-linked immunosorbent assay kits.
resultsThe median age of the 7 study participants was 62 (range, 45-66) years, time with short bowel syndrome was 6.6 (range, 2-29) years, and body mass index was 21.2 kg/m(2) (range, 19-27.7). Five patients had adaptive hyperphagia. Neither GHR nor PYY was significantly related to energy intake or absorption (GHR: R = 0.22 and R = -0.233, PYY: R = 0.10 and R = -0.13). Body mass index trended toward an inverse association with GHR (GHR: R = -0.540, P = .211).
conclusionThe rigorous adaptive hyperphagia seen in these patients with short bowel syndrome was not related to fasting GHR or PYY, suggesting the need to explore other mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.