ArticleCancer research2009
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation.Nature communications · 2022Article
- Quinone-rich fraction of Ardisia crispa (Thunb.) A. DC roots alters angiogenic cascade in collagen-induced arthritis.Inflammopharmacology · 2021Article
- Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling.Cells · 2021Review
- The Many Faces of JAKs and STATs Within the COVID-19 Storm.Frontiers in immunology · 2021Review
- Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agentOncotarget · 2020Article
- FGF Signaling Directs the Cell Fate Switch from Neurons to Astrocytes in the Developing Mouse Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Targeting Protein Kinases to Enhance the Response to anti-PD-1/PD-L1 Immunotherapy.International journal of molecular sciences · 2019Review
- Upregulation of TSPAN12 is associated with the colorectal cancer growth and metastasis.American journal of translational research · 2017Article
- FGFs: crucial factors that regulate tumour initiation and progression.Cell proliferation · 2016Review
- Genetic insights into the mechanisms of Fgf signaling.Genes & development · 2016Review
- Decreased expression of RPS15A suppresses proliferation of lung cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Knockdown of eIF3d inhibits cell proliferation through G2/M phase arrest in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2015Article
- Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular carcinoma and its relation to vascular invasion markers.Clinical & experimental metastasis · 2015Article
- Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer.BMC cancer · 2015Article
- Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling.BioMed research international · 2015Review
- GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.The Journal of biological chemistry · 2014Article
- Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation.Molecular cancer therapeutics · 2014Article
- Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- STAT5 and prolactin participate in a positive autocrine feedback loop that promotes angiogenesis.The Journal of biological chemistry · 2013Article
- SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses.American journal of translational research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers and activators of transcription (STAT) in mouse microvascular endothelial cells (EC). Both FGF2 and FGF8b activate STAT5 and to a lesser extent STAT1, but not STAT3. The FGF2-dependent activation of endothelial STAT5 was confirmed in vivo with the Matrigel plug angiogenesis assay. In tissue samples of human gliomas, a tumor type wherein FGF-induced angiogenesis is important, STAT5 is detected in tumor vessel EC nuclei, consistent with STAT5 activation. By forced expression of constitutively active or dominant-negative mutant STAT5A in mouse brain ECs, we further show that STAT5 activation is both necessary and sufficient for FGF-induced cell migration, invasion, and tube formation, which are key events in vascular endothelial morphogenesis and angiogenesis. In contrast, STAT5 is not required for brain EC mitogenesis. The cytoplasmic tyrosine kinases Src and Janus kinase 2 (Jak2) both seem to be involved in the activation of STAT5, as their inhibition reduces FGF2- and FGF8b-induced STAT5 phosphorylation and EC tube formation. Constitutively active STAT5A partially restores tube formation in the presence of Src or Jak2 inhibitors. These observations show that FGFs use distinct signaling pathways to induce angiogenic phenotypes. Together, our findings implicate the FGF-Jak2/Src-STAT5 cascade as a critical angiogenic FGF signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.