ArticleImmunology2009
Variable antigen uptake due to different expression of the macrophage mannose receptor by dendritic cells in various inbred mouse strains.
Article in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
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- Mannose receptor (MRC1) mediates uptake of dextran by bone marrow-derived macrophages.Molecular biology of the cell · 2024Article
- Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines.Frontiers in drug delivery · 2024Article
- Protein Concentration Affects the Food Allergen γ-Conglutin Uptake and Bacteria-Induced Cytokine Production in Dendritic Cells.Biomolecules · 2023Article
- Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity.npj aging · 2023Article
- Shape of ligand immobilized particles dominates and amplifies the macrophage cytokine response to ligands.PloS one · 2019Article
- Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance.Frontiers in immunology · 2018Review
- Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing.Biomaterials science · 2017Article
- Size-dependent accumulation of particles in lysosomes modulates dendritic cell function through impaired antigen degradation.International journal of nanomedicine · 2014Article
- Mannosylation of virus-like particles enhances internalization by antigen presenting cells.PloS one · 2014Article
- Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains.Respiratory research · 2012Article
- Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis.Cellular & molecular immunology · 2012Article
- Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection.Veterinary research · 2011Article
- Receptor-mediated and fluid-phase transcytosis of horseradish peroxidase across rat hepatocytes.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigen uptake by dendritic cells is essential for the induction of antigen-specific T-cell responses. Here, we investigate the ability of dendritic cells from different mouse strains to endocytose antigens. The uptake of different fluorescently labelled soluble antigens by bone marrow-derived dendritic cells from BALB/c, C57BL/6 and C3H/HeN mice was analysed by flow cytometry. Using transferrin as a specific marker for clathrin-mediated endocytosis, we observed no significant differences of transferrin uptake by dendritic cells from BALB/c, C57BL/6 and C3H/HeN mice. Similar results were obtained by analysing macropinocytosis with lucifer yellow. In contrast, analysing the uptake of ovalbumin, which is predominantly mediated by clathrin-mediated endocytosis via the macrophage mannose receptor, we found that dendritic cells from C3H/HeN mice take up three- to fivefold more ovalbumin than dendritic cells from BALB/c or C57BL/6 mice. Blocking the uptake of ovalbumin via the macrophage mannose receptor by using mannan led to a comparable uptake of ovalbumin by dendritic cells from all three mouse strains. Consistently, dendritic cells from C3H/HeN mice displayed significantly increased expression of the macrophage mannose receptor compared to dendritic cells from BALB/c or C57BL/6 mice. In conclusion, receptors involved in antigen uptake such as the macrophage mannose receptor may be differentially expressed and may explain variations of T-cell responses after vaccination in different individuals.
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