ReviewJournal of cellular and molecular medicine2009
Biomimetism, biomimetic matrices and the induction of bone formation.
Review in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Calcium Phosphates: A Key to Next-Generation In Vitro Bone Modeling.Advanced healthcare materials · 2024Review
- Guiding bone formation using semi-onlay calcium phosphate implants in an ovine calvarial model.Journal of tissue engineering and regenerative medicine · 2022Article
- Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.Stem cell research & therapy · 2017Article
- Functionalized Surface Geometries Induce: "Frontiers in physiology · 2017Review
- Ultrastructure Organization of Human Trabeculae Assessed by 3D sSAXS and Relation to Bone Microarchitecture.PloS one · 2016Article
- Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs.Journal of cellular and molecular medicine · 2013Article
- Article
- Induction of bone formation by transforming growth factor-beta2 in the non-human primate Papio ursinus and its modulation by skeletal muscle responding stem cells.Cell proliferation · 2010Article
- Soluble and insoluble signals sculpt osteogenesis in angiogenesis.World journal of biological chemistry · 2010Article
- The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus.Journal of cellular and molecular medicine · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionthe induction of bone formation, the emergence of the skeleton, of the vertebrates and of Homo species * Different strategies for the induction of bone formation. Biological significance of redundancy and synergistic induction of bone formation. Biomimetism and biomimetic matrices self-assembling the induction of bone formation The concavity: the shape of life and the induction of bone formation. Influence of geometry on the expression of the osteogenic phenotype. Conclusion and therapeutic perspectives on porous biomimetic matrices with intrinsic osteoinductivity Bone formation by induction initiates by invocation of osteogenic soluble molecular signals of the transforming growth factor-beta (TGF-beta) superfamily; when combined with insoluble signals or substrata, the osteogenic soluble signals trigger the ripple-like cascade of cell differentiation into osteoblastic cell lines secreting bone matrix at site of surgical implantation. A most exciting and novel strategy to initiate bone formation by induction is to carve smart self-inducing geometric concavities assembled within biomimetic constructs. The assembly of a series of repetitive concavities within the biomimetic constructs is endowed with the striking prerogative of differentiating osteoblast-like cells attached to the biomimetic matrices initiating the induction of bone formation as a secondary response. Importantly, the induction of bone formation is initiated without the exogenous application of the osteogenic soluble molecular signals of the TGF-beta superfamily. This manuscript reviews the available data on this fascinating phenomenon, i.e. biomimetic matrices that arouse and set into motion the mammalian natural ability to heal thus constructing biomimetic matrices that in their own right set into motion inductive regenerative phenomena initiating the cascade of bone differentiation by induction biomimetizing the remodelling cycle of the primate cortico-cancellous bone.
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Registered trials
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