SynthesisPigment cell & melanoma research2009
CTLA4 and generalized vitiligo: two genetic association studies and a meta-analysis of published data.
Synthesis in Pigment cell & melanoma research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis.Molecular biology reports · 2013Pooled it
- Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.The Journal of investigative dermatology · 2011Pooled it
- Vitiligo.Nature reviews. Disease primers · 2025Review
- Unraveling genetic predisposition and oxidative stress in vitiligo development and the role of artificial intelligence (AI) in diagnosis and management.Journal of medical biochemistry · 2025Article
- Vitiligo-like rash in a patient with lung cancer caused by sintilimab: A case report.World journal of clinical cases · 2025Article
- Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia.Scientific reports · 2025Article
- Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review.Journal of clinical medicine · 2024Review
- Spontaneous immunological activities in the target tissue of vitiligo-prone Smyth and vitiligo-susceptible Brown lines of chicken.Frontiers in immunology · 2024Article
- Current Concepts of Vitiligo Immunopathogenesis.Biomedicines · 2022Review
- Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.Molecular psychiatry · 2021Article
- Impact of cytotoxic T-lymphocyte-associated protein 4 codon 17 variant and expression on vitiligo risk.Journal of clinical laboratory analysis · 2021Article
- Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors.Journal of cardiovascular translational research · 2020Review
- Genetic profiling of a rare condition: co-occurrence of albinism and multiple primary melanoma in a Caucasian family.Oncotarget · 2017Article
- Genetics of Vitiligo.Dermatologic clinics · 2017Review
- Modern vitiligo genetics sheds new light on an ancient disease.The Journal of dermatology · 2013Review
- Association study between polymorphisms of CD28, CTLA4 and ICOS and non-segmental vitiligo in a Korean population.Experimental and therapeutic medicine · 2011Article
- Recent progress in the genetics of generalized vitiligo.Journal of genetics and genomics = Yi chuan xue bao · 2011Review
- Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.Thyroid : official journal of the American Thyroid Association · 2010Review
- Clinical characteristics and PTPN22 1858C/T variant analysis in Jordanian Arab vitiligo patients.Molecular diagnosis & therapy · 2010Article
- Vitiligo--part 1.Anais brasileiros de dermatologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Several lines of evidence have implicated the gene encoding cytotoxic T lymphocyte antigen 4 (CTLA4) in susceptibility to various autoimmune diseases. However, published studies of genetic association between CTLA4 polymorphisms and vitiligo have yielded conflicting results. Here, we describe two new genetic association studies of CTLA4 single-nucleotide polymorphisms (SNPs) and generalized vitiligo in two independent Romanian Caucasian (CEU) case-control cohorts. The first study, of SNPs rs1863800, rs231806, rs231775, rs3087243, rs11571302, rs11571297, and rs10932037, showed no allelic, genotypic, or haplotypic association with generalized vitiligo. The second study, of SNP rs231775, likewise showed no significant association. To enhance statistical power over that of any individual study, we carried out a meta-analysis that incorporated these two new studies and all other published genetic association studies of CTLA4 SNPs and vitiligo in CEU populations. While there was no association with vitiligo overall, the meta-analysis showed significant association of SNP rs231775 in that subgroup of vitiligo patients who also had other concomitant autoimmune diseases. Similarly, there was near-significant association in this same patient subgroup with several other CTLA4 SNPs that are in linkage disequilibrium with rs231775. Our results indicate that the association of CTLA4 with vitiligo is weak, and indeed may be secondary, driven by primary genetic association of CTLA4 with other autoimmune diseases that are epidemiologically associated with vitiligo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.