ArticleThe American journal of gastroenterology2009
Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3).
Article in The American journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.The Cochrane database of systematic reviews · 2020Pooled it
- No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: evidence from a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Possible etiology of improvements in both quality of life and overlapping gastroesophageal reflux disease by proton pump inhibitor treatment in a prospective randomized controlled trial.BMC gastroenterology · 2013Trial
- The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study.Journal of clinical medicine · 2023Article
- Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2019Review
- G protein beta 3(Oncotarget · 2018Article
- Genetic risk factors for perception of symptoms in GERD: an observational cohort study.Alimentary pharmacology & therapeutics · 2018Observational
- The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis.Gastroenterology research and practice · 2016Review
- Typical and atypical symptoms of gastro esophageal reflux disease: Does Helicobacter pylori infection matter?World journal of gastrointestinal pharmacology and therapeutics · 2015Article
- Helicobacter pylori Infection in Gastroesophageal Reflux Disease in the Asian Countries.Gastroenterology research and practice · 2015Review
- Overlap of functional dyspepsia and GERD--diagnostic and treatment implications.Nature reviews. Gastroenterology & hepatology · 2013Review
- Polymorphisms of the Serotonin Transporter Gene and G-Protein β3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia.Gut and liver · 2012Article
- Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome.Digestive diseases and sciences · 2011Article
- Genetic factors in the pathogenesis of gastroesophageal reflux disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2011Review
- Gastroesophageal Reflux Disease and Helicobacter pylori: What May Be the Relationship?Journal of neurogastroenterology and motility · 2010Article
- The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia.BMC medical genetics · 2010Article
- Dissecting GI phenotype-genotype relationships in GERD and dyspepsia: an SNP here and an SNP there!The American journal of gastroenterology · 2009Article
- Upper Gastrointestinal Sensitization And Symptom Generation.Journal of medicine and lifeReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVisceral hypersensitivity is involved in the etiology of reflux symptoms. Familial clustering and twin studies demonstrated a genetic predisposition to gastroesophageal reflux disease (GERD). G-protein-coupled receptors (GPCRs) mediate the response to acid, neurotransmitters and humoral factors modulating esophageal sensory function. Thus, polymorphisms in G-proteins are putative genetic factors contributing to GERD manifestation. A functional polymorphism in the G-protein beta3 subunit gene (GNB3) is associated with functional dyspepsia (FD), in which visceral hypersensitivity is implicated in symptom generation. We evaluated the association of the GNB3 C825T polymorphism with GERD and GERD subgroups classified according to esophageal acid exposure time, symptom-reflux correlation, or coexistence of FD and/or irritable bowel syndrome (IBS) symptoms.
methodsIn total, 363 GERD patients, defined as having esophageal pH < 4 > or = 6% of time and/or symptom index (SI) > or = 50% or symptom association probability (SAP) > or = 95%, participated. In addition, 373 healthy controls free of gastrointestinal symptoms were studied. Genotyping was performed by molecular beacon assay.
resultsThe CT genotype was more prevalent in GERD patients relative to healthy controls (adjusted odds ratio (OR)=1.43, 95% CI 1.04-1.98). GERD patients sensitive to physiological amounts of reflux displayed a higher OR (1.59), as did GERD patients with a positive symptom association score (1.50). The strongest association was detected in patients without concomitant FD and/or IBS symptoms (OR=1.66).
conclusionsGERD is associated with GNB3 C825T. The results for GERD subgroups support the hypothesis that enhanced perception of reflux events, as a consequence of the increased signal transduction upon GPCR activation associated with the 825T allele, underlies this association.
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