Evidence map›Paper›PMID 19174735›Full record

ArticleSexually transmitted diseases2009

Determinants of newly detected human papillomavirus infection in HIV-infected and HIV-uninfected injection drug using women.

Darcy F Phelan, Stephen J Gange, Linda Ahdieh-Grant, Shruti H Mehta, Gregory D Kirk, Keerti Shah, Patti Gravitt

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  16. Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Darcy F PhelanDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Stephen J Gange
Linda Ahdieh-Grant
Shruti H Mehta
Gregory D Kirk
Keerti Shah
Patti Gravitt
Johns Hopkins University · USNational Center for HIV/AIDS Viral Hepatitis STD and TB Prevention · US

Funding

WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
THE NATURAL HISTORY OF HIV INFECTION AMONG DRUG USERSR01DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1987 to 2011
$7.6M
Natural History of HIV Infection In Injection Drug UsersR56DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2012 to 2013
$3.2M
JOHNS HOPKINS SEXUALLY TRANSMITTED DISEASES--CRCU19AI038533 · NIAID · JOHNS HOPKINS UNIVERSITY · PI VLAHOV, DAVID H · 1995 to 1998
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NIAID NIH HHS U01 AI042590NIAID NIH HHS U19 AI038533NIAID NIH HHS U19 AI38533NIDA NIH HHS R01 DA004334NIDA NIH HHS R01 DA012568NIDA NIH HHS R01-DA04334NIDA NIH HHS R01-DA12568NIDA NIH HHS R56 DA004334
6 · The paper itself

Abstract

backgroundWe sought to identify factors associated with newly detected human papillomavirus (HPV) infection in a high-risk cohort of injection drug using women in Baltimore, MD.

methodsWe studied 146 HIV-infected and 73 HIV-uninfected female participants in a 5-year prospective HIV natural history study. We examined the association of sexual and nonsexual risk factors and newly detected type-specific HPV infection as determined by consensus PCR between consecutive visits.

resultsNewly detected HPV was more common among HIV-infected versus HIV-uninfected women (30% and 6%, respectively; P <0.01). Among the entire cohort, recent crack use (OR, 1.7; 95% CI, 1.1-2.6) and HIV infection/CD4 cell count were independent predictors for new HPV detection (HIV-uninfected as reference, OR, 4.6; 95% CI, 2.3-8.9, OR, 5.4; 95% CI, 2.8-10.3, and OR, 10.9; 95% CI, 5.5-21.7 for HIV-infected CD4 >500, 200-500, and <200, respectively). Among HIV-uninfected women, recent marijuana use was an independent predictor of newly detected HPV infection (OR, 3.5; 95% CI, 1.3-9.5).

conclusionsNewly detected HPV clearly increased with greater immunosuppression in HIV-infected injection drug users. Larger studies of HIV-uninfected and infected high-risk individuals are needed to clarify the independent associations of crack and marijuana use with new (or reactivated) HPV infection.

Indexed as

AdultBaltimoreCannabisCohort StudiesCrack CocaineFemaleHIV-1HIV InfectionsHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsProspective StudiesRisk FactorsRisk-TakingSexual BehaviorCrack Cocaine

Identifiers

PMID19174735
PMCPMC2888629
OpenAlexW1999994167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.