ArticleBMC cell biology2009
Zyxin is a novel interacting partner for SIRT1.
Article in BMC cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Zyxin Gene Expression in Patients with Varying Degrees of Coronary Artery Disease.International journal of molecular sciences · 2025Article
- The role of zyxin in signal transduction and its relationship with diseases.Frontiers in molecular biosciences · 2024Review
- Zyxin inhibits the epithelial-mesenchymal transition process in gastric cancer by upregulating SIRT1.MedComm · 2023Article
- Multiplexed labeling of cellular proteins with split fluorescent protein tags.Communications biology · 2021Article
- Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes.Frontiers in aging neuroscience · 2021Article
- Shared genes between Alzheimer's disease and ischemic stroke.CNS neuroscience & therapeutics · 2019Article
- Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants.Journal of Alzheimer's disease : JAD · 2019Article
- A Role for Nuclear Actin in HDAC 1 and 2 Regulation.Scientific reports · 2016Article
- Sirtuins in epigenetic regulation.Chemical reviews · 2015Review
- Article
- NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter.Retrovirology · 2014Article
- Bcl-2-associated transcription factor 1 interacts with fragile X-related protein 1.Acta biochimica et biophysica Sinica · 2014Article
- SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.Genes & cancer · 2013Article
- Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor β (TGFβ) signaling is essential for testicular aging and regulating testis size.Endocrinology · 2013Article
- Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium.American journal of human genetics · 2012Article
- Sirtuin biology and relevance to diabetes treatment.Diabetes management (London, England) · 2012Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSIRT1 is a mammalian homologue of NAD+-dependent deacetylase sirtuin family. It regulates longevity in several model organisms and is involved with cell survival, differentiation, metabolism among other processes in mammalian cells. SIRT1 modulates functions of various key targets via deacetylation. Recent studies have revealed SIRT1 protects neurons from axonal degeneration or neurodegeneration. Further, SIRT1 null mice exhibit growth retardation and developmental defects, suggesting its critical roles in neurons and development.
resultsTo identify novel binding partners for SIRT1 in the central nervous system, we performed yeast two-hybrid screening on human fetal brain cDNA library and found that zyxin is a possible binding partner. SIRT1 and zyxin transcript were both preferentially expressed in developmental mouse brain. Zyxin accumulates in the nucleus where it is co-localized with SIRT1 after treatment with leptomycin B in COS-7 cells. Furthermore, SIRT1 deacetylates zyxin, suggesting SIRT1 could interact with nuclear-accumulated zyxin and modulate its function through deacetylation.
conclusionZyxin could be a novel interacting partner of SIRT1. Zyxin is an adaptor protein at focal adhesion plaque, regulating cytoskeletal dynamics and signal transduction to convey signal from the ECM (extracellular matrix) to the nucleus. Our results raise the possibility that SIRT1 regulates signal transmission from ECM to the nucleus by modulating the functions of zyxin via deacetylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.