Trial reportBMC cardiovascular disorders2009
The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.
Trial report in BMC cardiovascular disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.BMC medical genetics · 2014Pooled it
- Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.Journal of the American College of Cardiology · 2013Pooled it
- Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity.Disease markers · 2021Article
- ANRIL rs1333049 C/G polymorphism and coronary artery disease in a North Indian population - Gender and age specific associations.Genetics and molecular biology · 2020Article
- Association ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System.Frontiers in cardiovascular medicine · 2017Article
- Association of rs10811656 on 9P21.3 with the risk of coronary artery disease in a Chinese population.Lipids in health and disease · 2016Article
- Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.Cardiovascular drugs and therapy · 2016Review
- Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran.Iranian biomedical journal · 2016Article
- Genetic ancestry is associated with measures of subclinical atherosclerosis in African Americans: the Jackson Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population.Anatolian journal of cardiology · 2015Article
- The chromosome 9p21 variant not predicting long-term cardiovascular mortality in Chinese with established coronary artery disease: an eleven-year follow-up study.BioMed research international · 2014Article
- The relationships between FAM5C SNP (rs10920501) variability and metabolic syndrome and inflammation in women with coronary heart disease.Biological research for nursing · 2013Article
- Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus.Circulation. Cardiovascular genetics · 2013Article
- Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15).Cardiovascular diabetology · 2012Article
- New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing.Nature communications · 2012Article
- The association between variants on chromosome 9p21 and inflammatory biomarkers in ethnically diverse women with coronary heart disease: a pilot study.Biological research for nursing · 2011Article
- The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease.European heart journal · 2010Article
- Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients.Cardiovascular diabetology · 2010Article
- Genetics of coronary artery disease: focus on genome-wide association studies.American journal of translational research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCase-control Genome-Wide Association Studies (GWAS) have identified single nucleotide polymorphisms (SNPs) at the 9p21 locus as risk factors for coronary artery disease (CAD). The locus does not contain a clear candidate gene. Hence, the results of GWAS have raised an intense interest in delineating the basis for the observed association. We analyzed association of 4 SNPs at the 9p21 locus with the severity and progression of coronary atherosclerosis, as determined by serial quantitative coronary angiograms (QCA) in the well-characterized Lipoprotein Coronary Atherosclerosis Study (LCAS) population. The LCAS is a randomized placebo-control longitudinal follow-up study in patients with CAD conducted to test the effects of fluvastatin on progression or regression of coronary atherosclerosis.
methodsExtensive plasma lipid levels were measured at the baseline and 2 1/2 years after randomization. Likewise serial QCA was performed at the baseline and upon completion of the study. We genotyped the population for 4 SNPs, previously identified as the susceptibility SNPs for CAD in GWAS, using fluorogenic 5' nuclease assays. We reconstructed the haplotypes using Phase 2, analyzed SNP and haplotype effects using the Thesias software as well as by the conventional statistical methods.
resultsOnly Caucasians were included since they comprised 90% of the study population (332/371 with available DNA sample). The 4 SNPs at the 9p21 locus were in tight linkage disequilibrium, leading to 3 common haplotypes in the LCAS population. We found no significant association between quantitative indices of severity of coronary atherosclerosis, such as minimal lumen diameter and number of coronary lesions or occlusions and the 9p21 SNPs and haplotypes. Likewise, there was no association between quantitative indices of progression of coronary atherosclerosis and the SNPs or haplotypes. Similarly, we found no significant SNP or haplotype effect on severity and progression of coronary atherosclerosis.
conclusionWe conclude the 4 SNPs at the 9p21 locus analyzed in this study do not impart major effects on the severity or progression of coronary atherosclerosis. The effect size may be very modest or the observed association of the CAD with SNPs at the 9p21 locus in the case-control GWAS reflect involvement of vascular mechanisms not directly related to the severity or progression of coronary atherosclerosis.
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