ReviewCNS drugs2009
Role of antiepileptic drugs in the management of eating disorders.
Review in CNS drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Antidepressants for polycystic ovary syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Treatment of alcohol dependence with low-dose topiramate: an open-label controlled study.BMC psychiatry · 2011Trial
- Pharmacological management of binge eating disorder.The mental health clinician · 2025Article
- Combination of sibutramine and topiramate for the treatment of obesity: the SIBAMATE retrospective cohort study : Sibutramine and topiramate for the treatment of obesity.Diabetology & metabolic syndrome · 2025Article
- Neurobehavioral Comorbidities in Canine Idiopathic Epilepsy: New Insights into Cognitive and Emotional Domains.Animals : an open access journal from MDPI · 2025Article
- Role of Non-Covalent Interactions in Carbonic Anhydrase I-Topiramate Complex Based on QM/MM Approach.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Inpatient treatment of anorexia nervosa with adjunctive valproate: a case series of 14 young and adolescent patients.Eating and weight disorders : EWD · 2022Article
- Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.Molecular psychiatry · 2018Article
- Article
- The role of the opioid system in binge eating disorder.CNS spectrums · 2015Review
- Topiramate in Alcohol Use Disorders: Review and Update.CNS drugs · 2015Review
- Weight regain after discontinuation of topiramate treatment in patients with migraine: a prospective observational study.CNS drugs · 2015Observational
- The pharmacological options in the treatment of eating disorders.ISRN pharmacology · 2013Article
- Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report.Case reports in medicine · 2012Article
- Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats.Journal of obesity · 2012Article
- Topiramate and the vision: a systematic review.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Obesity and psychotropics.CNS neuroscience & therapeutics · 2012Review
- Feeding and reward: perspectives from three rat models of binge eating.Physiology & behavior · 2011Review
- Topiramate-induced psychosis: the picture at 12 months.BMJ case reports · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence suggests that antiepileptic drugs (AEDs) may be useful in managing some eating disorders. In the present paper, we provide a brief overview of eating disorders, the rationale for using AEDs in the treatment of these disorders and review the data supporting the effectiveness of specific AEDs in the treatment of patients with eating disorders. In addition, the potential mechanisms of action of AEDs in these conditions are discussed. Of the available AEDs, topiramate appears to have the broadest spectrum of action as an anti-binge eating, anti-purging and weight loss agent, as demonstrated in two placebo-controlled studies in bulimia nervosa and three placebo-controlled studies in binge-eating disorder (BED) with obesity. Topiramate may also have beneficial effects in night-eating syndrome and sleep-related eating disorder, but controlled trials in these conditions are needed. The results of one small controlled study suggest that zonisamide may have efficacy in BED with obesity. However, both topiramate and zonisamide are associated with adverse effect profiles that may limit their use in patients with eating disorders. Phenytoin may be effective in some patients with compulsive binge eating, particularly if co-morbid EEG abnormalities are present, but available data are too varied to allow definitive conclusions to be made. Carbamazepine and valproate may be effective in treating patients with bulimia nervosa or anorexia nervosa when they are used to treat an associated psychiatric (e.g. mood) or neurological (e.g. seizure) disorder; otherwise, both agents, particularly valproate, are associated with weight gain. In conclusion, AEDs have an emerging role in the management of some eating disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.