ReviewJournal of cellular biochemistry2009
Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality.
Review in Journal of cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma.Clinical and translational medicine · 2025Article
- Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.eLife · 2021Article
- A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.Nucleic acids research · 2018Article
- Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors.Methods (San Diego, Calif.) · 2016Review
- Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase.Nucleic acids research · 2014Article
- Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.Journal of bacteriology · 2014Article
- Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.Cancer research · 2013Article
- Discovering new medicines targeting helicases: challenges and recent progress.Journal of biomolecular screening · 2013Review
- DNA helicases involved in DNA repair and their roles in cancer.Nature reviews. Cancer · 2013Review
- Structure and Mechanisms of SF1 DNA Helicases.Advances in experimental medicine and biology · 2013Article
- DNA helicases associated with genetic instability, cancer, and aging.Advances in experimental medicine and biology · 2013Article
- The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.Structure (London, England : 1993) · 2012Article
- Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection.Cancer research · 2012Article
- Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology.Seminars in cancer biology · 2010Review
- Molecular analyses of DNA helicases involved in the replicational stress response.Methods (San Diego, Calif.) · 2010Review
- Distinct roles of RECQ1 in the maintenance of genomic stability.DNA repair · 2010Review
- Human synthetic lethal inference as potential anti-cancer target gene detection.BMC systems biology · 2009Article
- Disease-causing missense mutations in human DNA helicase disorders.Mutation researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Designing strategies for anti-cancer therapy have posed a significant challenge. One approach has been to inhibit specific DNA repair proteins and their respective pathways to enhance chemotherapy and radiation therapy used to treat cancer patients. Synthetic lethality represents an approach that exploits pre-existing DNA repair deficiencies in certain tumors to develop inhibitors of DNA repair pathways that compensate for the tumor-associated repair deficiency. Since helicases play critical roles in the DNA damage response and DNA repair, particularly in actively dividing and replicating cells, it is proposed that the identification and characterization of synthetic lethal relationships of DNA helicases will be of value in developing improved anti-cancer treatment strategies. In this review, we discuss this hypothesis and current evidence for synthetic lethal interactions of eukaryotic DNA helicases in model systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.